Agomelatine:a potential novel approach for the treatment of memory disorder in neurodegenerative disease  

作　　者：Qiang Su Tian Li Guo-Wei Liu Yan-Li Zhang Jun-Hong Guo Zhao-Jun Wang Mei-Na Wu Jin-Shun Qi 

机构地区：[1]Key Laboratory of Cellular Physiology,Ministry of Education,Shanxi Medical University,Taiyuan,Shanxi Province,China [2]Department of Physiology,Shanxi Medical University,Taiyuan,Shanxi Province,China [3]Department of Neurology,First Hospital of Shanxi Medical University,Taiyuan,Shanxi Province,China [4]Department of Laboratory Medicine,Fenyang College of Shanxi Medical University,Fenyang,Shanxi Province,China [5]Department of Neurology,Sixth Hospital of Shanxi Medical University(General Hospital of Tisco),Taiyuan,Shanxi Province,China

出　　处：《Neural Regeneration Research》2023年第4期727-733,共7页中国神经再生研究（英文版）

基　　金：supported by Shanxi“1331 Project”Key Subjects Construction,No.1331KSC(to JSQ);Science Research Start-up Fund for Doctors of Shanxi Province,No.SD2011(to TL);Science Research Start-Up Fund for Doctors of Shanxi Medical University,No.XD2017(to TL)。

摘　　要：Agomelatine is a selective agonist of melatonin receptor 1A/melatonin receptor 1B(MT/MT)and antagonist of 5-hydroxytryptamine 2C receptors.It is used clinically to treat major depressive episodes in adults.The pro-chronobiological activity of agomelatine reconstructs sleep-wake rhythms and normalizes circadian disturbances via its agonistic effect of melatonin receptor 1A/melatonin receptor 1B,which work simultaneously to counteract depression and anxiety disorder.Moreover,by antagonizing neocortical postsynaptic 5-hydroxytryptamine 2C receptors,agomelatine enhances the release of dopamine and noradrenaline in the prefrontal cortex,increases the activity of dopamine and noradrenaline,and thereby reduces depression and anxiety disorder.The combination of these two effects means that agomelatine exhibits a unique pharmacological role in the treatment of depression,anxiety,and disturbance of the circadian rhythm.Emotion and sleep are closely related to memory and cognitive function.Memory disorder is defined as any forms of memory abnormality,which is typically evident in a broad range of neurodegenerative diseases,including Alzheimer’s disease.Memory impairment and cognitive impairment are common symptoms of neurodegenerative and psychiatric diseases.Therefore,whether agomelatine can improve memory and cognitive behaviors if used for alleviating depression and circadian-rhythm sleep disorders has become a research“hotspot”.This review presents the latest findings on the effects of agomelatine in the treatment of psychologic and circadian-rhythm sleep disorders in clinical trials and animal experiments.Our review evaluates recent studies on treatment of memory impairment and cognitive impairment in neurodegenerative and psychiatric diseases.

关 键 词：AGOMELATINE ANTIDEPRESSANT ANXIETY APATHY circadian-rhythm sleep disorder cognitive impairment depression melatonergic memory disorder mood disorder neurodegenerative disease 

分 类 号：R742.5[医药卫生—神经病学与精神病学]