Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain  

作　　者：Kyle Taing Lawrence Chen Han-Rong Weng 

机构地区：[1]Department of Basic Sciences,California Northstate University College of Medicine,Elk Grove,CA,USA

出　　处：《Neural Regeneration Research》2023年第4期763-768,共6页中国神经再生研究（英文版）

基　　金：supported by the NIH RO1 grant(NS107569)to HRW。

摘　　要：Neuroinflammation plays a critical role in the pathological process of multiple neurological disorders and pathological pain conditions.GPR109A,a Gi protein-coupled receptor,has emerged as an important therapeutic target for controlling inflammation in various tissues and organs.In this review,we summarized current data about the role of GPR109A in neuroinflammation.Specifically,we focused on the pharmacological features of GPR109A and signaling pathways used by GPR109A to ameliorate neuroinflammation and symptoms in Alzheimer’s disease,Parkinson’s disease,multiple sclerosis,stroke,and pathological pain conditions.

关 键 词：β-hydroxybutyrate cytokines HCAR2 LUPUS NEUROINFLAMMATION NEUROPATHIC NIACIN NOCICEPTION synaptic 

分 类 号：R741[医药卫生—神经病学与精神病学]