Ascorbic acid derived carbon dots promote circadian rhythm and contribute to attention deficit hyperactivity disorder  

作　　者：Jian Huang Yun Wang Zhaomin Zhong Yurong Ma Keru Deng Changhong Liu Hui Huang Yang Liu Xin Ding Zhenhui Kang 

机构地区：[1]School of Biology&Basic Medical Science,Soochow University,Suzhou 215123,China [2]Institute of Functional Nano and Soft Materials Laboratory(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices,Soochow University,Suzhou 215123,China [3]Division of Neonatology,Children’s Hospital of Soochow University,Suzhou 215003,China [4]Macao Institute of Materials Science and Engineering(MIMSE),MUST-SUDA Joint Research Center for Advanced Functional Materials,Macao University of Science and Technology,Taipa 999078,Macao,China

出　　处：《Nano Research》2022年第9期8247-8254,共8页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.31671216,81871193,51725204,21771132,51972216,and 52041202);the National MCF Energy R&D Program of China(No.2018YFE0306105);the National Key R&D Program of China(Nos.2020YFA0406104 and 2020YFA0406101);Innovative Research Group Project of the National Natural Science Foundation of China(No.51821002);Natural Science Foundation of Jiangsu Province(No.BK20190041);National College Students Innovation and Entrepreneurship Training Program(No.201710285042Z);Suzhou Scientific Program(No.SS202074);Key R&D program of Ningxia Hui Autonomous Region(No.2022BEG02006);Ningxia Autonomous Region flexible introduction of science and technology innovation team(No.2021RXTDLX08);Agricultural science and technology innovation project of Suzhou Science and Technology Development Plan(No.SNG2020074);Collaborative Innovation Center of Suzhou Nano Science&Technology,the 111 Project,and Suzhou Key Laboratory of Functional Nano&Soft Materials.

摘　　要：Attention deficit hyperactivity disorder(ADHD)is one of the most prevalent psychiatric disorders in children,and ADHD patients always display circadian abnormalities.While,the ADHD drugs currently used in clinic have strong side effects,such as psychosis,allergic reactions,and heart problems.Here,we demonstrated carbon dots derived from the ascorbic acid(VCDs)could strongly rescue the hyperactive and impulsive behaviour of a zebrafish ADHD disease model caused by per1b mutation.VCDs prolonged the circadian period of zebrafish for more than half an hour.In addition,the amplitude and circadian phase were also changed.The dopamine level was specifically increased,which may be caused by stimulation of the dopaminergic neuron development in the midbrain.Notably,it was found that the serotonin level was not altered by VCDs treatments.Also,the gene transcriptome effects of VCDs were discussed in present work.Our results provided the dynamic interactions of carbon dots with circadian system and dopamine signaling pathway,which illustrates a potential application of degradable and bio-safe VCDs for the treatment of the attention deficient and hyperactive disorder through circadian intervention.

关 键 词：carbon dots circadian rhythm DOPAMINE attention deficit hyperactivity disorder(ADHD) ZEBRAFISH 

分 类 号：R749.94[医药卫生—神经病学与精神病学]