Platinum nanoparticles promote breast cancer cell metastasis by disrupting endothelial barrier and inducing intravasation and extravasation  

作　　者：De-Ping Wang Jing Shen Chuan-Yue Qin Yong-Mei Li Li-Juan Gao Jian Zheng Yan-Lin Feng Zi Yan Xin Zhou Ji-Min Cao 

机构地区：[1]Key Laboratory of Cellular Physiology at Shanxi Medical University,Ministry of Education,and the Department of Physiology,Shanxi Medical University,Taiyuan 030001,China [2]Department of Medical Imaging,Shanxi Medical University,Taiyuan 030001,China

出　　处：《Nano Research》2022年第8期7366-7377,共12页纳米研究（英文版）

基　　金：the Key Medical Science and Technology Program of Shanxi Province(No.2020XM01);Shanxi“1331”Project Quality and Efficiency Improvement Plan(No.1331KFC);Applied Basic Research Program of Shanxi Province(Nos.201801D221408 and 201901D211320);Supporting Project for Returned Overseas Researchers of Shanxi Province(No.2020-081);partially by the National Natural Science Foundation of China(Nos.81801858,22007063,and 82170523)。

摘　　要：Breast cancer is a common malignancy in women with disappointing prognosis especially the triple-negative subtype.Recently,nanomedicine becomes a promising therapeutic strategy for breast cancer,such as platinum nanoparticles(PtNPs).Despite the promising anticancer effects of PtNPs,the safety of PtNPs remains to be fully evaluated.Herein,a series of cell and animal experiments demonstrate that PtNPs facilitate breast cancer metastasis by damaging the vascular endothelial barrier.PtNPs disrupt endothelial cell proliferation,migration and tube-like structure formation,destruct endothelial adhesions junctions and induce endothelial barrier leakiness in vitro most likely by stimulating intracellular reactive oxygen species(ROS)generation and altering the expression and conformation of endothelial junctional proteins,thus promoting intravasation and extravasation of the implanted 4T1 breast cancer cells and leading to cancer metastasis in female BALB/c nude mice in vivo.In addition,smaller PtNPs(5 nm)are more potent than larger PtNPs(70 nm)in exerting the above effects.The study provides the first evidence that PtNPs can promote breast cancer metastasis by damaging endothelial barrier.The unexpected detrimental effects of PtNPs should be considered in future nanomedicine designs for the treatment of breast cancer.

关 键 词：platinum nanoparticle ENDOTHELIUM cell junction breast cancer METASTASIS 

分 类 号：R737.9[医药卫生—肿瘤]