Immunosuppression Induced by Brain-Specific HDAC6 Knockdown Improves Aging Performance in Drosophila melanogaster  

作　　者：Yingying Zhao Hongwen Xuan Chao Shen Peiyi Liu Jing-Dong J.Han Wei Yu 

机构地区：[1]State Key Laboratory of Genetic Engineering,School of Life Sciences,Zhongshan Hospital,Fudan University,Shanghai 200438,China [2]CAS Key Laboratory of Computational Biology,Shanghai Institutes for Biological Sciences,CAS-MPG Partner Institute for Computational Biology,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,320 Yue Yang Road,Shanghai 200031,China [3]Peking-Tsinghua Center for Life Sciences,Center for Quantitative Biology(CQB),Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China

出　　处：《Phenomics》2022年第3期194-200,共7页表型组学（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(31771545,92049301,31821002,91329302,and 31210103916);China Ministry of Science and Technology(2015CB964803,2016YFE0108700,and 2016YFA0500600),and Max Planck fellowship to J.D.J.H.

摘　　要：HDAC6 is involved in several biological processes related to aging-associated diseases.However,it was unknown whether HDAC6 could directly regulate lifespan and healthspan.We found that HDAC6 knockdown induced transcriptome changes to attenuate the aging changes in the Drosophila head,particularly on the inflammation and innate immunity-related genes.Whole-body knockdown of HDAC6 extended lifespan in the fly,furthermore brain-specific knockdown of HDAC6 extended both lifespan and healthspan in the fly.Our results established HDAC6 as a lifespan regulator and provided a potential anti-aging target.

关 键 词：HDAC6 AGING DROSOPHILA INFLAMMATION Innate immunity Motor neuron 

分 类 号：Q96[生物学—昆虫学]