Synaptosome microRNAs:emerging synapse players in aging and Alzheimer’s disease  

作　　者：Subodh Kumar 

机构地区：[1]Center of Emphasis in Neuroscience,Department of Molecular and Translational Medicine [2]Paul L.Foster School of Medicine,Texas Tech University Health Sciences Center,El Paso,TX,USA

出　　处：《Neural Regeneration Research》2023年第6期1275-1276,共2页中国神经再生研究（英文版）

基　　金：National Institute of Aging (NIA), National Institute of Health (NIH) for the funding the K99/R00 awards- K99AG065645 and R00AG065645 to SK

摘　　要：Synaptosome:Synapses are the most critical portion of neuron connections,necessary for cellular organization of the brain.Synapse integrity is uttermost important for healthy brain functioning.Any perturbation in the synapse structure and/or function initiates neurological disorders.Synapses are the prime targets that are smashed in almost all neurodegenerative diseases.The vital components of synapse are essential for neurotransmission,synaptic plasticity and overall synapse function.Synapse dysfunctions are well studied in Alzheimer’s disease(AD)and other neurodegenerative diseases(Gowda et al.,2021).The best way to study the synapse dysfunctions in neurological diseases is the biochemical analysis of“synaptosome”.

关 键 词：ALZHEIMER DISEASES 

分 类 号：R749.16[医药卫生—神经病学与精神病学]