从蛋白质基因组学视角出发的精准肿瘤学  

Precision oncology from a proteogenomics perspective

作　　者：黄雨柔 吴松锋 舒坤贤[1] 朱云平[2,3] HUANG Yurou;WU Songfeng;SHU Kunxian;ZHU Yunping(School of Bioinformatics,Chongqing University of Posts and Telecommunications,Chongqing 400065,China;National Center for Protein Sciences(Beijing),Beijing Institute of Life Omics,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 102206,China;Proteome Research Center,Beijing 102206,China)

机构地区：[1]重庆邮电大学生物信息学院,重庆400065 [2]军事科学院军事医学研究院生命组学研究所国家蛋白质科学中心(北京),北京102206 [3]北京蛋白质组研究中心,北京102206

出　　处：《生物工程学报》2022年第10期3616-3627,共12页Chinese Journal of Biotechnology

基　　金：国家重点研发计划(2021YFA1301603);蛋白质组学国家重点实验室开放课题(SKLP-O2020005)。

摘　　要：癌症是一种机制复杂的异质性疾病,需要有针对性的精准医疗策略。精准医疗的发展离不开基因组学的飞速发展,但基因组学在分子表型分析中具有一定的局限性,蛋白质基因组学应运而生。蛋白质基因组学是蛋白质组学和基因组学的融合学科。文中描述了基因组学分析的局限性,强调了蛋白质基因组学的重要性,旨在从蛋白质基因组的视角重新了解精准肿瘤学。此外,还简要介绍了蛋白质基因组学在精准肿瘤学中的应用,对相关的公共数据项目进行了描述,最后,提出了现阶段需要克服的困难。Cancer is a heterogeneous disease with complex mechanisms that requires targeted precision medicine strategies.The growth of precision medicine is indispensable from the rapid development of genomics.However,genomics has certain limitations in molecular phenotype analysis,proteogenomics thus arose at the right time.Proteogenomics is the merging of proteomics and genomics.This review describes the limitations of genomic analysis and highlights the importance of proteogenomics to re-understand precision oncology from a proteogenomic perspective.In addition,the application of proteogenomics in precision oncology is briefly introduced,the related public data projects are described,and finally,the challenges that need to be addressed at this stage are proposed.

关 键 词：癌症 蛋白质基因组学 精准肿瘤学 公共数据库 

分 类 号：R730[医药卫生—肿瘤]