DLG7/DLGAP5 as a potential therapeutic target in gastric cancer  

作　　者：Kang Li Xiangsheng Fu Ping Wu Bianba Zhaxi Hanhuan Luo Qijie Li 

机构地区：[1]Department of Gastroenterology,People’s Hospital of Tibet Autonomous Region,Lhasa,Tibet 850000,China [2]Department of Gastroenterology,First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610041,China [3]Department of Occupational Diseases,The Second Affiliated Hospital of Chengdu Medical College Nuclear Industry 416 Hospital,Chengdu,Sichuan 610051,China [4]Department of Anesthesiology,Laboratory of Anesthesia and Critical Care Medicine,Translational Neuroscience Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China.

出　　处：《Chinese Medical Journal》2022年第13期1616-1618,共3页中华医学杂志（英文版）

基　　金：supported by the Key Technology Projects of Tibet Autonomous Region(No.2015XZ01G22);PostDoctor Research Project,West China Hospital,Sichuan University(No.2018HXBH082);China Postdoctoral Science Foundation(No.2019M653413).

摘　　要：To the Editor:Gastric cancer is a highly invasive disease.An estimated 1.09 million cases were diagnosed and 770,000 gastric cancer-related deaths occurred only in 2020.[1]Advanced gastric cancer can no longer be subjected to surgery and can only be treated with sequential lines of chemotherapy.However,the survival period is usually short.[2]Therefore,it is of utmost importance to identify new and more effective treatments and therapeutic targets to combat gastric cancer.Disc large homolog 7(DLG7)is the microtubule-associated protein encoded by the DLG associated protein 5(DLGAP5)gene,which affects chromosome rearrangement and gene stability[3];thus,its overexpression may cause canceration.Some studies revealed that DLGAP5 is highly expressed in gastric cancer tissues,suggesting that it may also have a role in this disease.However,the role and mechanism of DLGAP5 in gastric cancer are still unclear.[4]Therefore,this study aimed at exploring the role of DLGAP5 in the growth and invasion of gastric cancer as well as the potential use as a therapeutic target to combat this disease.

关 键 词：THERAPEUTIC GASTRIC CANCER 

分 类 号：R735.2[医药卫生—肿瘤]