Roles of organelle-specific autophagy in hepatocytes in the development and treatment of non-alcoholic fatty liver disease  

作　　者：Yizhi Zhang Yu Chen 

机构地区：[1]Fourth Department of Liver Disease(Difficult and Complicated Liver Diseases and Artificial Liver Center),Beijing You’an Hospital Affiliated to Capital Medical University,Beijing 100069,China [2]Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research,Beijing 100069,China

出　　处：《Chinese Medical Journal》2022年第14期1673-1681,共9页中华医学杂志（英文版）

基　　金：supported by grants from the Beijing Advanced Innovation Center for Big Data-Based Precision Medicine(No.PXM2021_014226_000026);the Capital Funds for Health Improvement and Research(No.2021-1G-2181).

摘　　要：Non-alcoholic fatty liver disease(NAFLD)is a disorder of lipid metabolism.The lipotoxic intermediates of lipid metabolism cause mitochondrial dysfunction and endoplasmic reticulum stress.Organelle-specific autophagy is responsible for the removal of dysfunctional organelles to maintain intracellular homeostasis.Lipophagy contributes to lipid turnover by degrading lipid droplets.The level of autophagy changes during the course of NAFLD,and the activation of hepatocyte autophagy might represent a method of treating NAFLD.

关 键 词：AUTOPHAGY Lipophagy MITOPHAGY Reticulophagy Non-alcoholic fatty liver disease 

分 类 号：R575.5[医药卫生—消化系统]