Alzheimer’s disease risk after COVID-19:a view from the perspective of the infectious hypothesis of neurodegeneration  

作　　者：Eugenia Olivera Albany Sáez Lila Carniglia Carla Caruso Mercedes Lasaga Daniela Durand 

机构地区：[1]Instituto de Investigaciones Biomédicas INBIOMED UBA-CONICET,Facultad de Medicina,Universidad de Buenos Aires,Argentina

出　　处：《Neural Regeneration Research》2023年第7期1404-1410,共7页中国神经再生研究（英文版）

基　　金：supported by grants to DD from Agencia Nacional de Promoción de la Investigación,el desarrollo tecnológico y la innovación(ANPCyT,PICT N°03893).

摘　　要：In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration.We wondered how SARS-CoV-2 could be related to the amyloid-βcascade and how it could lead to the pathological hallmarks of the disease.We also predict a paradigm change in clinical medicine,which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.

关 键 词：Alzheimer amyloid beta antimicrobial cognitive decline COVID-19 infectious hypothesis long-term sequelae NEURODEGENERATION NEUROINFLAMMATION neurological symptoms NEUROTROPISM SARS-CoV-2 

分 类 号：R749.16[医药卫生—神经病学与精神病学]