Lights for epilepsy:can photobiomodulation reduce seizures and offer neuroprotection?  

作　　者：Napoleon Torres-Martinez Stephan Chabardes John Mitrofanis 

机构地区：[1]University of Grenoble Alpes,FDD and CEA-LETI,Clinatec,Grenoble,France

出　　处：《Neural Regeneration Research》2023年第7期1423-1426,共4页中国神经再生研究（英文版）

摘　　要：Epilepsy is synonymous with individuals suffering repeated“fits”or seizures.The seizures are triggered by bursts of abnormal neuronal activity,across either the cerebral cortex and/or the hippocampus.In addition,the seizure sites are characterized by considerable neuronal death.Although the factors that generate this abnormal activity and death are not entirely clear,recent evidence indicates that mitochondrial dysfunction plays a central role.Current treatment options include drug therapy,which aims to suppress the abnormal neuronal activity,or surgical intervention,which involves the removal of the brain region generating the seizure activity.However,~30%of patients are unresponsive to the drugs,while the surgery option is invasive and has a morbidity risk.Hence,there is a need for the development of an effective non-pharmacological and non-invasive treatment for this disorder,one that has few side effects.In this review,we consider the effectiveness of a potential new treatment for epilepsy,known as photobiomodulation,the use of red to near-infrared light on body tissues.Recent studies in animal models have shown that photobiomodulation reduces seizure-like activity and improves neuronal survival.Further,it has an excellent safety record,with little or no evidence of side effects,and it is non-invasive.Taken all together,this treatment appears to be an ideal treatment option for patients suffering from epilepsy,which is certainly worthy of further consideration.

关 键 词：cell death GLIOSIS inflammation infrared mitochondria NON-PHARMACOLOGICAL red SEIZURE 

分 类 号：R742.1[医药卫生—神经病学与精神病学]