GLIOSIS

作品数：32被引量：90H指数：6
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相关领域：医药卫生更多>>
相关作者：刘颖孙景军叶诸榕更多>>
相关机构：复旦大学上海医学院深圳市眼科医院更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》《Neuroimmunology and Neuroinflammation》《沈阳药科大学学报》更多>>
相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金更多>>
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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions
《Neural Regeneration Research》2025年第7期2116-2128,共13页Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen 
supported by the Army Laboratory Animal Foundation of China,No.SYDW[2020]22(to TC);the Shaanxi Provincial Key R&D Plan General Project of China,No.2022SF-236(to YM);the National Natural Science Foundation of China,No.82202070(to TC)。
A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain unclear.Therefore,we established an animal model of weightlessness via tail suspension to ...
关键词：glial fibrous acidic protein GLIOSIS Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness 
Targeting tau in Alzheimer's disease:from mechanisms to clinical therapy被引量：7
《Neural Regeneration Research》2024年第7期1489-1498,共10页Jinwang Ye Huali Wan Sihua Chen Gong-Ping Liu 
supported by the National Natural Science Foundation of China,No.82101493(to JY)。
Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older adults.Primary features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neur...
关键词：ACETYLATION Alzheimer’s disease cognitive deficits GLIOSIS mitochondria damage NEUROINFLAMMATION phosphorylation synaptic impairments TAU tau immunotherapy 
Effect of Sonic hedgehog gene-modified bone marrow mesenchymal stem cells on graft-induced retinal gliosis and retinal ganglion cells survival in diabetic mice
《International Journal of Ophthalmology(English edition)》2024年第1期34-41,共8页Tong Wang Hai-Chun Li Jin Ma Xi-Ling Yu 
Supported by the Natural Science Foundation of Guangdong Province(No.2018A0303130293,No.2023A1515012470).
AIM:To investigate the effects of Sonic hedgehog(Shh)gene-modified bone marrow mesenchymal stem cells(MSCs)on graft-induced retinal gliosis and retinal ganglion cells(RGCs)survival in diabetic mice.METHODS:Bone marrow...
关键词：mesenchymal stem cells Sonic hedgehog signaling reactive gliosis diabetic retinopathy retinal ganglion cells 
'Hippocampal innate inflammatory gliosis only'-the future role of surgery in a novel temporal lobe epilepsy syndrome
《Neural Regeneration Research》2023年第12期2657-2658,共2页Alexander Grote Daniel Delev 
Epilepsy is one of the most common neurological conditions affecting more than 50 million people worldwide(https://www.who.int/news-room/fact-sheets/detail/epilepsy).Despite numerous antiseizure medications(ASM),appro...
关键词：EPILEPSY al. SURGERY 
Lights for epilepsy:can photobiomodulation reduce seizures and offer neuroprotection?
《Neural Regeneration Research》2023年第7期1423-1426,共4页Napoleon Torres-Martinez Stephan Chabardes John Mitrofanis 
Epilepsy is synonymous with individuals suffering repeated“fits”or seizures.The seizures are triggered by bursts of abnormal neuronal activity,across either the cerebral cortex and/or the hippocampus.In addition,the...
关键词：cell death GLIOSIS inflammation infrared mitochondria NON-PHARMACOLOGICAL red SEIZURE 
Neurovascular unit in diabetic retinopathy:pathophysiological roles and potential therapeutical targets
《Eye and Vision》2023年第3期11-29,共19页Shen Nian Amy C.Y.Lo Yajing Mi Kai Ren Di Yang 
supported by the National Natural Science Foundation of China(Grant Nos.81873740 and 81860174);Natural Science Basic Research Plan of Shaanxi Province(Grant No.2020JM-612);Applied Basic Research Program of Yunnan Province(Grant No.2017FE468-143);National Fund Cultivation Project in Xi'an Medical University(Grant No.2017GJFY29).
Diabetic retinopathy(DR),one of the common complications of diabetes,is the leading cause of visual loss in working-age individuals in many industrialized countries.It has been traditionally regarded as a purely micro...
关键词：Diabetic retinopathy Neurovascular unit NEURODEGENERATION GLIOSIS INFLAMMATION treatment 
Efficacy of acupuncture on repair of glial scars in rats with traumatic brain injury被引量：2
《Journal of Traditional Chinese Medicine》2023年第2期329-336,共8页ZENG Hai CAO Luxi PANG Zhao ZHAO Sisi WANG Shiqi LIN Zhuowen CHEN Minan LIN Shujun ZHANG Yimin 
Supported by National Natural Science Foundation of China:Explore the Effect and Mechanism of Acupuncture for Neuroinflammation and Glial Scars After Traumatic Brain Injury Based on the Signaling Pathway of TLR2/4-NFκB(No.81574066);National Natural Science Foundation of China:Explore the Effect of Acupuncture on Brain Function Remodeling and the Benign Bidirectional Regulation to Autophagy After TBI(No.81873362);National Natural Science Foundation of China:Basing on the Theory of Bidirectional Benign Regulation to Investigate the Mechanism of Acupuncture Regulating Microglia-mediated Immune Imbalance to Promote Nerve Repair After TBI(No.82174483);National Natural Science Foundation of China:Based on Iron Metabolic Pathway to Explore the Mechanism of Electroacupuncture Inhibits Ferroptosis to Reduce TBI Nerve Injury(No.82205249);China Postdoctoral Science Foundation:the Effect and Mechanism of Electroacupuncture in Promoting Neural Function Repair by Regulating Iron Metabolism in Neurons of TBI Rats(2022M710912);Natural Science Foundation of Guangdong Province:the Effect and Mechanism of Acupuncture on the Linkage of Neuron Autophagy and Apoptosis after TBI Based on PI3K/AKT/mTOR Signaling Pathway(2021A1515011219);Natural Science Foundation of Guangdong Province:the Effect and Mechanism of Acupuncture on Microglial Polarization Mediated Immune Homeostasis After TBI Based on TREM2/STAT6/NFκB Signaling Pathway(2021A1515110146)。
OBJECTIVE:To explore the underlying mechanism of acupuncture on nerve repair by investigating its effect on the differentiation of glial cells and the repair of glial scars.METHODS:Sprague-Dawley rats were randomly al...
关键词：ACUPUNCTURE ASTROCYTES MICROGLIA GLIOSIS brain injuries TRAUMATIC 
Necroptosis plays a crucial role in the exacerbation of retinal injury after blunt ocular trauma
《Neural Regeneration Research》2023年第4期922-928,共7页Yu Huan Xiu-Quan Wu Tao Chen Ya-Nan Dou Bo Jia Xin He Dong-Yu Wei Zhou Fei Fei Fei 
supported by the National Natural Science Foundation of China,No.81600738;the Youth Development Project of Air Force Medical University,No.21QNPY072(both to FF)。
Retinal injury after blunt ocular trauma may directly affect prognosis and lead to vision loss.To investigate the pathological changes and molecular mechanisms involved in retinal injury after blunt ocular trauma,we e...
关键词：Beagle dogs blunt ocular trauma GLIOSIS M1 microglia Müller cells NECROPTOSIS NEUROINFLAMMATION retinal ganglion cells retinal injury weight drop injury 
ROS-removing nano-medicine for navigating inflammatory microenvironment to enhance anti-epileptic therapy被引量：2
《Acta Pharmaceutica Sinica B》2023年第3期1246-1261,共16页Zheng Zhou Keying Li Yongchao Chu Chao Li Tongyu Zhang Peixin Liu Tao Sun Chen Jiang 
support from the National Natural Science Foundation of China (81872808,82121002);Key Projects of Shanghai Science Founation (19JC1410800,China);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01,China);ZJLab
As a neurological disorder in the brain,epilepsy is not only associated with abnormal synchronized discharging of neurons,but also inseparable from non-neuronal elements in the altered microenvironment.Anti-epileptic ...
关键词：EPILEPSY Polymeric micelle Reactive oxygen species Inflammation GLIOSIS NEUROPROTECTION 
Intravitreal slow-release dexamethasone alleviates traumatic proliferative vitreoretinopathy by inhibiting persistent inflammation and Müller cell gliosis in rabbits被引量：2
《International Journal of Ophthalmology(English edition)》2023年第1期22-32,共11页Yi-Ming Zhao Rong-Sha Sun Fang Duan Fang-Yu Wang Yu-Jie Li Xiao-Bing Qian Jie-Ting Zeng Yao Yang Xiao-Feng Lin 
Supported by National Natural Science Foundation of China(No.81974135,No.81900851)。
AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabb...
关键词：ocular trauma proliferative vitreoretinopathy GLIOSIS Ozurdex INFLAMMATION rabbit 
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