Neurovascular unit in diabetic retinopathy:pathophysiological roles and potential therapeutical targets  

作　　者：Shen Nian Amy C.Y.Lo Yajing Mi Kai Ren Di Yang 

机构地区：[1]Department of Pathology,Xi'an Medical University,Xi'an,Shaanxi Province,China [2]Department of Ophthalmology,LKS Faculty of Medicine,The University of Hong Kong,Hong Kong,China [3]Institute of Basic Medicine Science,Xi'an Medical University,Xian,Shaanxi Province,China [4]Department of Biochemistry and Molecular Biology,Xi'an Medical University,Xi'an,Shaanxi Province,China [5]Department of Ophthalmology,First Affiliated Hospital of Kunming Medical University,Kunming Medical University,Kunming,Yunnan Province,China

出　　处：《Eye and Vision》2023年第3期11-29,共19页眼视光学杂志（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.81873740 and 81860174);Natural Science Basic Research Plan of Shaanxi Province(Grant No.2020JM-612);Applied Basic Research Program of Yunnan Province(Grant No.2017FE468-143);National Fund Cultivation Project in Xi'an Medical University(Grant No.2017GJFY29).

摘　　要：Diabetic retinopathy(DR),one of the common complications of diabetes,is the leading cause of visual loss in working-age individuals in many industrialized countries.It has been traditionally regarded as a purely microvascular disease in the retina.However,an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the retina.Deterioration of neural retina could precede microvascular abnormalities in the DR,leading to microvascular changes.Furthermore,disruption of interactions among neurons,vascular cells,glia and local immune cells,which collectively form the neurovascular unit,is considered to be associated with the progression of DR early on in the disease.Therefore,it makes sense to develop new therapeutic strategies to prevent or reverse retinal neurodegeneration,neuroinflammation and impaired cell-cell interactions of the neurovascular unit in early stage DR.Here,we present current perspectives on the pathophysiology of DR as a neurovascular disease,especially at the early stage.Potential novel treatments for preventing or reversing neurovascular injuries in DR are discussed as well.

关 键 词：Diabetic retinopathy Neurovascular unit NEURODEGENERATION GLIOSIS INFLAMMATION treatment 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]