New unexpected role for Wolfram Syndrome protein WFS1:a novel therapeutic target for Alzheimer’s disease?  

作　　者：Shuo Chen Diana Acosta Hongjun Fu 

机构地区：[1]Department of Neuroscience,Biomedical Sciences Graduate Program,The Ohio State University,Columbus,OH,USA [2]Department of Neuroscience,The Ohio State University,Columbus,OH,USA

出　　处：《Neural Regeneration Research》2023年第7期1501-1502,共2页中国神经再生研究（英文版）

基　　金：supported by awards K01-AG056673,R56-AG066782-01 and R01-AG075092-01(to HF)from the National Institute on Aging of the National Institutes of Health;supported by the award of the W81XWH1910309(to HF)from the Department of Defense.

摘　　要：Selective vulnerability of excitatory neurons in Alzheimer’s disease(AD):AD is the most common form of dementia;however,the pathogenesis of AD is largely unknown.One of the characteristic features of AD is the formation of intracellular neurofibrillary tangles(NFTs).NFTs are abnormal accumulates of misfolded tau protein,which may eventually cause neuronal death and neurodegeneration(Jack et al.,2018).In the early stages of AD progression,not all neurons are equally vulnerable to tau aggregates.Previous studies have shown that large pyramidal neurons in the entorhinal cortex(EC)are specifically vulnerable to pathological tau accumulation(Fu et al.,2017).This selective vulnerability of excitatory neurons to tau pathology is one of the fundamental questions needed to be answered in AD research.

关 键 词：ALZHEIMER TAU CORTEX 

分 类 号：R749.16[医药卫生—神经病学与精神病学]