家族遗传性前列腺癌研究进展  

Research progress of familial and hereditary prostate cancer

作　　者：张挺维 韦煜 叶定伟 朱耀 Tingwei Zhang;Yu Wei;Dingwei Ye;Yao Zhu(Department of Urinary Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China)

机构地区：[1]复旦大学附属肿瘤医院泌尿外科,上海市200032

出　　处：《中国肿瘤临床》2022年第23期1201-1206,共6页Chinese Journal of Clinical Oncology

摘　　要：前列腺癌在我国的发病率逐年上升,且具有高度遗传性。随着测序技术的发展及相关研究的进展,家族遗传性前列腺癌获得更加深入的认识。越来越多的基因突变、单核苷酸多态性和拷贝数变异等被证实与前列腺癌的发生发展有着密不可分的关系,针对这些可能的致病因素开发出多种药物,并且疗效已为临床试验所证实,对家族遗传性前列腺癌特征的描述也为临床管理带来了新的思考。本文总结现有文献,针对家族遗传性前列腺癌的特点、遗传基础、治疗、检测及筛查进行综述。The incidence of prostate cancer,a highly hereditary disease,is increasing every year in China.With the development of sequencing technologies and the increasing related researches,we have a better understanding of familial and hereditary prostate cancer wherein increasing number of gene mutations,single nucleotide polymorphisms,and copy number variations have been confirmed to be closely associated with the pathogenesis of prostate cancer.Several drugs targeting the possible pathogenic factors have been developed,and their efficacy has been confirmed via clinical trials.A better in-depth understanding of the characteristics of familial and hereditary prostate cancer is crucial for developing new approaches in the clinical management of the disease.In this review,we evaluated the characteristics,genetic basis,treatment,detection,and screening of familial and hereditary prostate cancer.

关 键 词：遗传性前列腺癌 遗传位点 基因检测 癌症筛查 

分 类 号：R737.25[医药卫生—肿瘤]