A ROS-Stimulus-Responsive Nanocarrier Loading with Guanidine-Modified Hydroxycamptothecin Prodrug for Enhanced Anti-Tumor Efficacy  

作　　者：Zhilin Liu Haiyang Yu Na Shen Zhaohui Tang Xuesi Chen 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022(China) [2]University of Science and Technology of China,Hefei 230026(China)

出　　处：《CCS Chemistry》2020年第5期305-316,共12页中国化学会会刊（英文）

基　　金：support for this work was provided by the Ministry of Science and Technology of China(no.2018ZX09711003-012);National Natural Science Foundation of China(Project nos.51503202,51673189,51873206,51833010,and 51520105004).

摘　　要：We report a reactive oxygen species(ROS)-stimulus-responsive phenylboronic acid pinacol ester nanocarrier,loaded with guanidine-modified 10-hydroxycamptothecin(HCPT)prodrug,to create a drug delivery-base nanomedicine.The prodrug was stuck tightly in the nanocarrier with over 99%drug-loading efficiency due to the superposition of hydrogen bonds from guanidine and carboxyl,hydrophobic interaction,π–πstacking interaction from phenylboronic acid pinacol ester,and the HCPT prodrug.The aqueous stability of the phenylboronic acid pinacol ester nanocarrier improved remarkably after drug loading because of the interaction between the prodrug and the nanocarrier.Thus,the nanomedicine could realize ROS-triggered disassembly at the tumor sites,release the cell-penetrating prodrug,and achieve improved cellular uptake than the HCPT alone.The results of in vivo antitumor determination demonstrated three-fold inhibition of tumor growth rate of the ROS-stimulus-responsive nanomedicine,compared with HCPT,and the side effects of the prodrug complex reduced significantly.Therefore,our approach offers a promising strategy for the enhancement of antitumor efficacy.

关 键 词：ROS NANOMEDICINE cancer therapy PRODRUG NANOCARRIER 

分 类 号：R730[医药卫生—肿瘤]