Hydrogen Sulfide-Specific and NIR-Light-Controllable Synergistic Activation of Fluorescent Theranostic Prodrugs for Imaging-Guided Chemo- Photothermal Cancer Therapy  

作　　者：Ge Xu Wei Guo Xianfeng Gu Zhijun Wang Rongchen Wang Tianli Zhu He Tian Chunchang Zhao 

机构地区：[1]Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center,Institute of Fine Chemicals,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237 [2]Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203.

出　　处：《CCS Chemistry》2020年第4期527-538,共12页中国化学会会刊（英文）

基　　金：support by the National Natural Science Foundation of China(21672062,21874043,21572039,and 21788102);Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX03);the Program of Introducing Talents of Discipline to Universities(B16017).

摘　　要：Theranostic prodrugs are promising for cancer medicine;however,the inability to activate these systems exclusively at the desired tumor location compromises the specificity and efficacy of cancer treatment.Here,we developed a fluorescent theranostic nanoprodrug with synergistic hydrogen-sulfidespecific and near-infrared(NIR)-light-controllable activation for imaging-guided chemo-photothermal cancer therapy.This nanoprodrug system was fabricated by the inclusion of hydrogen sulfide(H2S)-activatable small molecule to the theranostic prodrug and a photothermal transducer in the interior of a NIR-light-responsive container.

关 键 词：THERANOSTIC PRODRUG hydrogen sulfide NIR fluorescence light-controllable cancer therapy 

分 类 号：R730.5[医药卫生—肿瘤] O657.3[医药卫生—临床医学]