Amyotrophic lateral sclerosis disease burden:doing better at getting better  

作　　者：Cinzia Volonté Susanna Amadio 

机构地区：[1]National Research Council-Institute for Systems Analysis and Computer Science“Antonio Ruberti”,Cellular Neurobiology Unit,IRCCS Fondazione Santa Lucia,Rome,Italy [2]Cellular Neurobiology Unit,IRCCS Fondazione Santa Lucia,Rome,Italy

出　　处：《Neural Regeneration Research》2023年第8期1728-1729,共2页中国神经再生研究（英文版）

基　　金：supported by FATALSDRUG Project(Progetti di Ricerca@CNR)from National Research Council,Italy(to CV)。

摘　　要：Amyotrophic lateral sclerosis(ALS)is classified as a multigenic,multifactorial,and heterogeneous neurodegenerative/neuroinflammatory disease that slays especially upper and lower motor neurons controlling voluntary muscle activity.After the insurgence that is characterized by typical symptoms such as weakness in the limbs and muscle twitches,the disease rapidly evolves into progressive muscle atrophy,paralysis,and lastly death occurring by respiratory failure usually within 2-4 years of diagnosis.

关 键 词：SCLEROSIS PARALYSIS RESPIRATORY 

分 类 号：R741[医药卫生—神经病学与精神病学]