Inhibition of Notch 1 signaling in the subacute stage after stroke promotes striatal astrocyte-derived neurogenesis  

作　　者：Xiao-Zhu Hao Cheng-Feng Sun Lu-Yi Lin Chan-Chan Li Xian-Jing Zhao Min Jiang Yan-Mei Yang Zhen-Wei Yao 

机构地区：[1]Department of Radiology,Huashan Hospital,Fudan University,Shanghai,China [2]Institutes of Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai,China

出　　处：《Neural Regeneration Research》2023年第8期1777-1781,共5页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.81801660(to XZH)and 81771788(to YMY)。

摘　　要：Inhibition of Notch1 signaling has been shown to promote astrocyte-derived neurogenesis after stroke.To investigate the regulatory role of Notch1 signaling in this process,in this study,we used a rat model of stroke based on middle cerebral artery occlusion and assessed the behavior of reactive astrocytes post-stroke.We used theγ-secretase inhibitor N-[N-(3,5-diuorophenacetyl)-1-alanyl]-S-phenylglycine t-butylester(DAPT)to block Notch1 signaling at 1,4,and 7 days after injury.Our results showed that only administration of DAPT at 4 days after stroke promoted astrocyte-derived neurogenesis,as manifested by recovery of white matter fiber bundle integrity on magnetic resonance imaging,which is consistent with recovery of neurologic function.These findings suggest that inhibition of Notch1 signaling at the subacute stage post-stroke mediates neural repair by promoting astrocyte-derived neurogenesis.

关 键 词：ASTROCYTE diffusion kurtosis imaging magnetic resonance imaging middle cerebral artery occlusion N-[N-(3 5-diuorophenacetyl)-1-alanyl]-Sphenylglycine t-butylester neural repair NEUROGENESIS neuron Notch1 signaling subacute stage 

分 类 号：R741[医药卫生—神经病学与精神病学]