New insights into the biological roles of immune cells in neural stem cells in post-traumatic injury of the central nervous system  

作　　者：Ning He Xing-Jia Mao Yue-Min Ding Tong Zuo Ying-Ying Chen Lin-Lin Wang 

机构地区：[1]Department of Basic Medicine Sciences,and Department of Orthopaedics of Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China [2]School of Medicine,Hangzhou City University,Hangzhou,Zhejiang Province,China [3]University of Chicago College,University of Chicago,Chicago,IL,USA [4]Department of Basic Medicine Sciences,and Department of Obstetrics of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China

出　　处：《Neural Regeneration Research》2023年第9期1908-1916,共9页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82172527 and 81972138 (to LLW)。

摘　　要：Traumatic injuries in the central nervous system,such as traumatic brain injury and spinal cord injury,are associated with tissue inflammation and the infiltration of immune cells,which simultaneously affect the self-renewal and differentiation of neural stem cells.Howeve r,the tissue repair process instigated by endogenous neural stem cells is incapable of restoring central nervous system injuries without external intervention.Recently,resident/peripheral immune cells have been demonstrated to exert significant effects on neural stem cells.Thus,the resto ration of traumatic injuries in the central nervous system by the immune intervention in neural stem cells represents a potential therapeutic method.In this review,we discuss the roles and possible mechanisms of immune cells on the selfrenewal and differentiation of neural stem cells along with the prognosis of central nervous system injuries based on immune intervention.Finally,we discuss remaining research challenges that need to be considered in the future.Further elucidation of these challenges will fa cilitate the successful application of neural stem cells in central nervous system injuries.

关 键 词：B cells central nervous system injury MACROPHAGES MICROGLIA neural stem cells spinal cord injury T cells traumatic brain injury 

分 类 号：R741[医药卫生—神经病学与精神病学]