Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments  

作　　者：Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López 

机构地区：[1]Área de Biología Celular,Instituto de Biomedicina,Campus de Vegazana s/n,Universidad de León,León,Spain [2]Neural Therapies SL.Edif.Institutos de Investigación.Planta baja.Local B43.Campus de Vegazana s/n.León.Spain [3]Department of Medicina,Cirugía y Anatomía Veterinaria,University of León,León,Spain [4]Department of Pharmacology,Tulane University School of Medicine,New Orleans,LA,USA [5]Department of Neurology,David Geffen School of Medicine at University of California(UCLA),Los Angeles,CA,USA [6]Department of Life Sciences,Imperial College London(ICL),London,UK [7]Department of Clinical and Movement Neurosciences,UCL Queen Square Institute of Neurology,London,UK

出　　处：《Neural Regeneration Research》2023年第9期1961-1967,共7页中国神经再生研究（英文版）

基　　金：supported by MINECO and FEDER funds:ref CPP2021-008855 and RTC-2015-4094-1,Junta de Castilla y León ref.LE025P1 7;Neural Therapies SL;ref.NTDev-01 (all to AFL and JMGO)。

摘　　要：The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies.

关 键 词：ANTI-INFLAMMATORIES ASTROCYTE axonal sprouting cylinder test DOUBLECORTIN focal brain ischemia glial scar inflammation neuroprotection new neuron generation transient stroke 

分 类 号：R743.31[医药卫生—神经病学与精神病学]