The role of fibronectin in multiple sclerosis and the effect of drug delivery across the blood-brain barrier  

作　　者：Shuang-Shuang Wei Le Chen Feng-Yuan Yang Si-Qi Wang Peng Wang 

机构地区：[1]Ningxia Key Laboratory of Craniocerebral Diseases,School of Clinical Medicine,Ningxia Medical University,Yinchuan,Ningxia Hui Autonomous Region,China [2]Ningxia Key Laboratory of Craniocerebral Diseases,Ningxia Medical University,Yinchuan,Ningxia Hui Autonomous Region,China

出　　处：《Neural Regeneration Research》2023年第10期2147-2155,共9页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82001282(to PW)and 81960232(to PW);Overseas Students’Innovation and Entrepreneurship Individual Project of Ningxia(2021)(to PW);Youth Talents Supporting Program of Ningxia Medical University and Ningxia,Nos.XT2019018(to PW),TJGC2019081(to PW);College Students’Innovation and En trepreneurship Training Program,No.X202210752038(to FYY)。

摘　　要：Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease progression.Previous research has shown that the extracellular matrix is associated with remyelination failure because remodeling of the matrix often fails in both chronic and progressive multiple sclerosis.Fibronectin aggregates are assembled and persistently exist in chronic multiple sclerosis,thus inhibiting remyelination.Although many advances have been made in the mechanisms and treatment of multiple sclerosis,it remains very difficult for drugs to reach pathological brain tissues;this is due to the complexity of brain structure and function,especially the existence of the blood-brain barrier.Therefore,herein,we review the effects of fibronectin aggregates on multiple sclerosis and the efficacy of different forms of drug delivery across the blood-brain barrier in the treatment of this disease.

关 键 词：blood-brain barrier brain delivery EXOSOMES extracellular matrix fibronectin aggregates FIBRONECTIN intestinal flora multiple sclerosis remyelination failure REMYELINATION 

分 类 号：R943[医药卫生—药剂学]