The role of Rho GTPase family in cochlear hair cells and hearing  

作　　者：Yu-Bei Dai Xiang Gao Dong Liu Jie Gong 

机构地区：[1]School of Life Science,Nantong Laboratory of Development and Diseases,Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education,Co-innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2023年第10期2167-2172,共6页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Jiangsu Province,No.BK20221377(to JG);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China,No.22KJB180023(to JG)。

摘　　要：Rho GTPases are essential regulators of the actin cytoskeleton.They are involved in various physiological and biochemical processes such as the regulation of cytoskeleton dynamics,development,proliferation,survival,and regeneration.During the development of cochlear hair cells,Rho GTPases are activated by various extracellular signals through membrane receptors to further stimulate multiple downstream effectors.Specifically,RhoA,Cdc42,and Rac1,members of the classical subfamily of the Rho GTPase family,regulate the development and maintenance of cilia by inducing the polymerization of actin monomers and stabilizing actin filaments.In addition,they also regulate the normal morphology orientation of ciliary bundles in auditory hair cells,which is an important element of cell polarity regulation.Moreover,the actin-related pathways mediated by RhoA,Cdc42,and Rac1 also play a role in the motility of outer hair cells,indicating that the function of Rho GTPases is crucial in the highly polar auditory sensory system.In this review,we focus on the expression of RhoA,Cdc42,and Rac1 in cochlear hair cells and how these small molecules participate in ciliary bundle morphogenesis and cochlear hair cell movement.We also discuss the progress of current research investigating the use of these small molecules as drug targets for deafness treatment.

关 键 词：actin assembly auditory sensory neurons cell polarity cell proliferation ELECTROMOTILITY hair cell hearing loss MORPHOGENESIS Rho GTPases STEREOCILIA 

分 类 号：R741[医药卫生—神经病学与精神病学]