STEREOCILIA

作品数：12被引量：10H指数：2
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相关领域：医药卫生更多>>
相关作者：胡凌翔张鲁平更多>>
相关机构：南通大学上海交通大学医学院附属新华医院更多>>
相关期刊：《Science China(Life Sciences)》《Journal of Bio-X Research》《Journal of Otology》《Applied Mathematics and Mechanics(English Edition)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Deletion of Luzp Does Not Cause Hearing Loss in Mice
《Neuroscience Bulletin》2024年第10期1519-1528,共10页Cheng Cheng Guangjie Zhu Kaijian Wang Chuan Bu Siyu Li Yue Qiu Jie Lu Xinya Ji Wenli Hao Junguo Wang Chengwen Zhu Ye Yang Yajun Gu Xiaoyun Qian Chenjie Yu Xia Gao 
supported by grants from the National Natural Science Foundation of China (81970884,81900941,81970885,82371157,82171145,82271173,and 81771019);the Natural Science Foundation of Jiangsu Province (BK20190121 and BK20200133);the China Postdoctoral Science Foundation (2020M681555);a Distinguished Young Scholarship supported by the Medical Science and Technology Development Foundation,Nanjing Department of Health (JQX20003).
Deafness is the prevailing sensory impairment among humans,impacting every aspect of one's existence.Half of congenital deafness cases are attributed to genetic factors.Studies have shown that Luzp2 is expressed in ha...
关键词：Hearing loss Luzp2 Hair cell Stereocilia Ribbon synapse 
The role of Rho GTPase family in cochlear hair cells and hearing被引量：1
《Neural Regeneration Research》2023年第10期2167-2172,共6页Yu-Bei Dai Xiang Gao Dong Liu Jie Gong 
supported by the Natural Science Foundation of Jiangsu Province,No.BK20221377(to JG);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China,No.22KJB180023(to JG)。
Rho GTPases are essential regulators of the actin cytoskeleton.They are involved in various physiological and biochemical processes such as the regulation of cytoskeleton dynamics,development,proliferation,survival,an...
关键词：actin assembly auditory sensory neurons cell polarity cell proliferation ELECTROMOTILITY hair cell hearing loss MORPHOGENESIS Rho GTPases STEREOCILIA 
Dock4 is required for the maintenance of cochlear hair cells and hearing function
《Fundamental Research》2023年第4期557-569,共13页Guodong Hong Xiaolong Fu Jieyu Qi Buwei Shao Xuan Han Yuan Fang Shuang Liu Cheng Cheng Chengwen Zhu Junyan Gao Xia Gao Jie Chen Ming Xia Wei Xiong Renjie Chai 
This work was supported by grants from National Key R&D Program of China(2021YFA1101300,2020YFA0112503,2020YFA0113600);the Strategic Priority Research Program of the Chinese Academy of Science(XDA16010303);the National Natural Science Foundation of China(82030029,81970882,82071013,81870721,92149304,82000984);the Natural Science Foundation of Jiangsu Province(BE2019711);the Science and Technology Department of Sichuan Province(2021YFS0371);the Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022);the China National Postdoctoral Program for Innovative Talents(BX20200082);the Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(SKLGE-2109).
Auditory hair cells(HCs)are the mechanosensory receptors of the cochlea,and HC loss or malfunction can result from genetic defects.Dock4,a member of the Dock180-related protein superfamily,is a guanine nucleotide exch...
关键词：Hair cell STEREOCILIA Oxidative stress APOPTOSIS Hearing loss Dock4 
Polarized condensates confer row identity of hair cell stereocilia
《Journal of Molecular Cell Biology》2022年第7期78-79,共2页Yingdong Shi Lin Lin Chao Wang Jinwei Zhu 
This work was supported by grants from the National Key R&D Program of China(2018YFA0507900 to 1.Z,2019YFA0508402 to C.W.);the National Natural Science Foundation of China(32122036,U2032122,and 31770779 to 1.Z;22122703,91953110,and 32170767 to C.W.);the Science and Technology Commission of Shanghai Municipality(20S 11900200);the Interdisciplinary Innovative Talent Training Program of Shanghai Jiao Tong University(to 1.Z.);the Scientific Research Foundation for Youth Scholars of Shanghailiao Tong University(AF0890029 to L.L.)。
Sound waves are converted into electric signals by hair bundles(also known as stereocilia)in the cochlear hair cells.Stereocilia,a cluster of actin protrusions at the apical surface of hair cells,are organized into ro...
关键词：electrical FIGURE shorter 
Disruption of the autism-related gene Pak1 causes stereocilia disorganization,hair cell loss,and deafness in mice被引量：2
《Journal of Genetics and Genomics》2021年第4期324-332,共9页Cheng Cheng Yilin Hou Zhonghong Zhang Yanfei Wang Ling Lu Liyan Zhang Pei Jiang Song Gao Qiaojun Fang Chengwen Zhu Junyan Gao Xufeng Liu Wei Xie Zhengping Jia Zhigang Xu Xia Gao Renjie Chai 
supported by grants from Strategic Priority Research Program of the Chinese Academy of Science(XDA16010303);the National Natural Science Foundation of China(81570921,82030029,81970882,81970884,81900941,81771019,81700913);Natural Science Foundation of Jiangsu Province(BE2019711,BK20190121);the China Postdoctoral Science Foundation(2020M681555);Shenzhen Fundamental Research Program(JCYJ20190814093401920)。
Several clinical studies have reported that hearing loss is correlated with autism in children.However,little is known about the underlying mechanism between hearing loss and autism.p21-activated kinases(PAKs)are a fa...
关键词：PAK1 Hearing loss Synapse Hair bundle ERM 
Myosin XVA:dancing at the tips of the stereocilia
《Journal of Bio-X Research》2020年第2期60-65,共6页Du Haibo Li Nana Xu Zhigang 
National Key Basic Research Program of China(No.2018YFC1003600);the National Natural Science Foundation of China(No.81771001);Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology(No.SPKLACDB-2019000);the Fundamental Research Funds of Shandong University(No.2018JC025).
Myosins comprise a large superfamily of adenosine triphosphatases(ATPases)that interact with actin filaments to generate motility or force.Unconventional myosins are implicated in diverse cellular processes including ...
关键词：hair cells inner ear MYO15A MYOSINS STEREOCILIA 
Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice被引量：1
《Frontiers of Medicine》2019年第6期690-704,共15页Yuqin Men Xiujuan Li Hailong Tu Aizhen Zhang Xiaolong Fu Zhishuo Wang Yecheng Jin Congzhe Hou Tingting Zhang Sen Zhang Yichen Zhou Boqin Li Jianfeng Li Xiaoyang Sun Haibo Wang Jiangang Gao 
Tprn encodes the taperin protein,which is concentrated in the tapered region of hair cell stereocilia in the inner ear.In humans,TPRN mutations cause autosomal recessive nonsyndromic deafness(DFNB79)by an unknown mech...
关键词：TPRN STEREOCILIA stereociliary rootlet actin filament CRISPR/Cas9 HEARING 
Numerical simulation based on three-dimensional model of inner stereocilia被引量：2
《Applied Mathematics and Mechanics(English Edition)》2017年第7期997-1006,共10页Wenjuan YAO Yiqiang CHEN 
supported by the National Natural Science Foundation of China(Nos.11272200 and 11572186)
A three-dimensional inner stereocilium model is established by PATRAN. According to the relevant data, the corresponding pressure is applied to one side of the inner stereocilia. The top displacement of the inner ster...
关键词：inner stereocilium Castigliano＇s theorem cochlear duct 
Mechanical model of organ of Corti
《Applied Mathematics and Mechanics(English Edition)》2017年第6期867-876,共10页Yiqiang CHEN Wenjuan YAO Shaofeng LIU 
Project supported by the National Natural Science Foundation of China(Nos.11272200 and11572186)
According to the vibration characteristics of the organ of Corti （OC）, seven hypotheses are made to simplify the structure of the model, and a mechanical OC model is established. Using the variational principle, a d...
关键词：organ of Corti （OC） variational principle hardening of outer hair cells（OHCs） hardening of outer stereocilia threshold shift 
Bistability in Ephaptic Coupling as a Possible Memory Element Explored through a Colloid Interptation of Stereocilia Bistability
《Journal of Electromagnetic Analysis and Applications》2015年第3期107-114,共8页Michelangelo Rossetto 
When the processes of neurons are in close proximity they effectively couple to each other in a process termed Ephaptic coupling. This coupling occurs without the membranes touching when the space between them is some...
关键词：Ephaptic Hair Cell STEREOCILIA COLLOID BISTABILITY Memory 
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