Clinical and pathophysiological understanding of the hepatorenal syndrome:Still wrong or still not exactly right?  

作　　者：Benjamin Wilde Ali Canbay Antonios Katsounas 

机构地区：[1]Department of Nephrology,University of Duisburg-Essen,University Hospital Essen,Essen 45147,Germany [2]Department of Medicine,Ruhr University Bochum,Bochum 44892,Germany

出　　处：《World Journal of Clinical Cases》2023年第6期1261-1266,共6页世界临床病例杂志

摘　　要：The hepatorenal syndrome(HRS)is one major extrahepatic complication of endstage liver diseases.While circulatory dysregulation is considered as primary etiology for HRS,cirrhosis-related(systemic)inflammation and/or cardial dysfunction may also play a key pathogenic role in HRS development.Exclusion of other causes of acute kidney injury(AKI)is required for diagnosis of HRS-AKI by the definition of the International Club of Ascites.However,the pathophysiology of HRS is not understood completely and there are still limited therapeutic options.Reversibility of renal dysfunction after liver transplantation indicates that HRS-AKI is a functional disorder caused by altered cellular function.The interplay between systemic inflammation and the onset of kidneyrelated hypometabolism may have a key role and needs to be studied in depth.This minireview challenges simplified views of the HRS in the context of diagnostics and therapy stressing the need for further evidence to advance the knowledge on this syndrome.

关 键 词：Hepatorenal syndrome Liver disease CIRRHOSIS INFLAMMATION Chronic kidney disease Acute kidney injury 

分 类 号：R575[医药卫生—消化系统]