单核细胞增生李斯特菌营养胁迫表型特征及调控机制  

Advance on Phenotypic Characteristics and Regulatory Mechanisms of Nutrient Stress of Listeria monocytogenes

作　　者：胡敏敏 董庆利[1] 秦晓杰 胡丽丽 王园 刘阳泰[1] Hu Minmin;Dong Qingli;Qin Xiaojie;Hu Lili;Wang Yuan;Liu Yangtai(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093;Shanghai Zhongqiao Vocational and Technical University,Shanghai 201514)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]上海中侨职业技术大学,上海201514

出　　处：《中国食品学报》2023年第2期374-382,共9页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金项目(32102095)。

摘　　要：单核细胞增生李斯特菌(单增李斯特菌)能引发侵袭性李斯特菌病,是一类可导致严重后果的食源性致病菌。单增李斯特菌广泛分布于环境复杂多变的食品供应链各环节中,其通过调整自身生理状态以应对营养缺乏等胁迫条件带来的生存挑战,继而对食品安全造成威胁。本文重点介绍营养胁迫条件下单增李斯特菌表型特征和可能的调控机制,包括生物膜形成能力、抗性和毒性,以及σB、(p)ppGpp和sRNA等相关调控因子,以便了解单增李斯特菌营养胁迫下的抗逆生存机制,为进一步开展相关精准防控工作提供参考。Listeria monocytogenes(L.monocytogenes)is an important food-borne pathogen causing invasive listeriosis.This pathogen is widely distributed in various links of the food supply chain with complex and changeable environment.L.monocytogenes presents an exceptional ability to survive in adverse environment such as nutrient deficiency by adjusting its physiological state,posing a serious threat to food safety.This review focused on the phenotypic characteristics and possible regulatory mechanisms of L.monocytogenes under nutrient stress conditions,including biofilm formation ability,resistance and virulence,as well as regulatory factors such asσB,(p)ppGpp and sRNA.This study can help to understand the survival mechanism of L.monocytogenes under nutrient stress,and provide reference for controlling this pathogen.

关 键 词：单增李斯特菌 表型特征 σB因子 (p)ppGpp SRNA 

分 类 号：TS201.3[轻工技术与工程—食品科学]