RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes  

作　　者：Lili Yu Lei Jiang Meng Wu Wenlong Dou Kaiyuan Ji Jianlong Zhou Jinchul Kim Yang Xu 

机构地区：[1]Department of Cardiology,Cardiovascular Key Lab of Zhejiang Province,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China [2]Department of Medical Oncology,Key Laboratory of Cancer Prevention and Intervention,Ministry of Education,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China [3]Cancer Center,Zhejiang University,Hangzhou 310058,China [4]School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,China [5]Ageing Research Center,Korea Research Institute of Bioscience and Biotechnology,Deajeon 34141,Korea

出　　处：《Protein & Cell》2023年第2期149-152,共4页蛋白质与细胞（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.81902506,81930084).

摘　　要：Dear Editor,The pathogenesis of nasopharyngeal carcinoma(NPC)is closely associated with the infection of Epstein Barr virus(EBV)(Hau et al.,2020).However,the mechanisms underlying NPC tumorigenesis remain unclear,leading to a lack of therapeutic targets to effectively treat NPC.RNA helicase MTR4,which is a compo-nent of the virus-induced cofactor complex linking viral RNA to exosome for degradation,is overexpressed in NPCs of patients.The expression levels of MTR4 are inversely correlated with the prognosis of NPC patients.

关 键 词：NASOPHARYNGEAL TUMORIGENESIS 

分 类 号：R739.63[医药卫生—肿瘤]