Mechanosensitive Piezo1 channel regulation of microglial cell function and implications to neurodegenerative diseases and neuroinflammation  

作　　者：Mo Zhang Philippa Malko Lin-Hua Jiang 

机构地区：[1]Department of Physiology and Pathophysiology,and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province,Xinxiang Medical University,Xinxiang,Henan Province,China [2]School of Biomedical Sciences,Faculty of Biological Sciences,University of Leeds,Leeds,UK [3]A4245-Transplantation,Immunology and Inflammation,Faculty of Medicine,University of Tours,Tours,France

出　　处：《Neural Regeneration Research》2023年第11期2385-2386,共2页中国神经再生研究（英文版）

基　　金：A PhD Studentship from University of Leeds (to PM);Start-Up Fund from Xinxiang Medical University (to LHJ)。

摘　　要：Microglial cells are the key immunocompetent cells in the central nervous system (CNS) and play a crucial role in CNS health and disease (Paolicelli et al.,2022).Under the homeostatic conditions,microglial cells assume diverse and dynamic states,depending upon interactions with neighboring cells and structures in local contextual settings,continuously patrol brain parenchyma utilizing their highly mobile fine processes,phagocytize protein aggregates,unwanted synapses and cells to maintain CNS health,and secrete neurotrophic factors to support neuronal function (Colonna and Butovsky,2017;Paolicelli et al.,2022).

关 键 词：INFLAMMATION DISEASES function 

分 类 号：R741[医药卫生—神经病学与精神病学]