Targeting glial metabolism in neurodegenerative diseases:detail matters  

作　　者：Ruqayya Afridi Kyoungho Suk 

机构地区：[1]Department of Pharmacology,School of Medicine,Kyungpook National University,Daegu,South Korea [2]Department of Biomedical Sciences,BK21 PLUS KNU Biomedical Convergence Program,School of Medicine,Kyungpook National University,Daegu,South Korea [3]Brain Science and Engineering Institute,Kyungpook National University,Daegu,South Korea

出　　处：《Neural Regeneration Research》2023年第11期2393-2394,共2页中国神经再生研究（英文版）

基　　金：National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF-2017R1A5A2015391,2020M3E5D9079764)(to KS)。

摘　　要：Neurodegenerative diseases,a group of disorders associated with advanced age,are typified by the disease-specific accumulation of mutant proteins and neuroinflammation.For decades,treatment modalities for these disorders have focused on addressing neuronal malfu nction,which has resulted in the failure of therapies.Recent studies have identified the crucial role of glial cells in exacerbating neurodegenerative processes via the release of neuroinflammatory mediators.Glia,the major immune component of the central nervous system (CNS),undergo numerous phenotypic transitions and regulate the outcomes of various pathologies (Afridi et al.,2022).

关 键 词：DEGENERATIVE METABOLISM DISEASES 

分 类 号：R741.02[医药卫生—神经病学与精神病学]