多酚类化合物基于非编码RNA调控发挥抗肿瘤及辐射增敏作用研究进展  

Research Progress on Anti-tumor and Radiosensitization of Polyphenols Based on Non-coding RNA Regulation

作　　者：李雪 李俐 王小龙 郝利民 刘永奇 刘可可 张雪梅 鲁吉珂 伊娟娟 LI Xue;LI Li;WANG Xiaolong;HAO Limin;LIU Yongqi;LIU Keke;ZHANG Xuemei;LU Jike;YI Juanjuan(School of Life Sciences,Zhengzhou University,Zhengzhou 450001,China;Henan Yinfeng Bioengineering Technology Co.,Ltd.,Zhengzhou 450001,China;Systems Engineering Institute,Academy of Military Sciences(AMS),Beijing 100010,China)

机构地区：[1]郑州大学生命科学学院,河南郑州450001 [2]河南省银丰生物工程技术有限公司,河南郑州450001 [3]军事科学院系统工程研究院,北京100010

出　　处：《食品科学》2023年第5期222-230,共9页Food Science

基　　金：国家自然科学基金青年科学基金项目(31900296);郑州大学青年人才企业合作创新团队支持计划项目(32320422);郑州大学技术开发(合作)横向项目(20210442A,20210327A)。

摘　　要：恶性肿瘤严重危害人类生命健康,放疗是目前治疗恶性肿瘤常用的方法之一。然而电离辐射会引起肿瘤细胞的辐射抗性并损伤正常组织细胞,限制了其在临床上的应用。多酚类天然产物不仅可以提高肿瘤细胞的辐射敏感性,同时又能缓解辐射对机体产生的负面效应,在肿瘤治疗中发挥着重要作用。非编码RNA在许多疾病的发生发展中起着重要作用,近年来研究发现多酚类物质在抗肿瘤及辐射增敏方面与非编码RNA的调控存在一定关联。基于此,本文综述天然产物多酚抗肿瘤和辐射增敏的作用及其机制,并基于非编码RNA调控层面阐释其作用效果,以期为肿瘤等疾病的干预治疗及相关特医膳食食品的开发提供新思路。Malignant tumor seriously endangers human life and health.Radiotherapy is currently one of the most common treatments for malignant tumor.However,ionizing radiation(IR)can cause radiation resistance of tumor cells and damage normal tissue cells,thereby limiting the clinical application of radiotherapy.Natural polyphenols not only can improve the radiosensitivity of tumor cells,but also can alleviate the negative effects of IR on the body,thus playing an important role in tumor treatment.Dysregulation of non-coding RNA plays an important role in the occurrence and development of many diseases.In recent years,studies have found that the anti-tumor and radiosensitization effects of polyphenols are associated with non-coding RNA regulation.In this context,this paper reviews the anti-tumor and radiosensitization effects of natural polyphenols and their mechanisms,especially from the perspective of non-coding RNA regulation,in order to provide new ideas for the intervention and treatment of tumors and other diseases,as well as the development of food products for special medical purposes.

关 键 词：多酚 电离辐射 非编码RNA 抗肿瘤 辐射增敏 

分 类 号：TS201.4[轻工技术与工程—食品科学]