胆盐水解酶酶学性质与基因结构研究进展  

Progress on Enzymatic Properties and Gene Structure of Bile Salt Hydrolase

作　　者：卢方云 杨彪 马晶晶 杨静 李鹏鹏 徐为民[1,2,3] 王道营 邹烨[1,2,3] LU Fangyun;YANG Biao;MA Jingjing;YANG Jing;LI Pengpeng;XU Weimin;WANG Daoying;ZOU Ye(College of Food and Bioengineering,Jiangsu University,Zhenjiang 212001,China;Institute of Agricultural Products Processing,Jiangsu Academy of Agricultural Science,Nanjing 210014,China;Key Laboratory of Agricultural Products Cold Chain Logistics Technology,Ministry of Agriculture and Rural Affairs,Nanjing 210014,China)

机构地区：[1]江苏大学食品与生物工程学院,江苏镇江212001 [2]江苏省农业科学院农产品加工所,江苏南京210014 [3]农业农村部农产品冷链物流技术重点实验室,江苏南京210014

出　　处：《食品工业科技》2023年第8期469-475,共7页Science and Technology of Food Industry

基　　金：国家现代农业产业技术体系资助(CARS-41)。

摘　　要：胆盐水解酶(Bile salt hydrolase,BSH)广泛存在于哺乳动物胃肠道中,是肠道菌群在生长、繁殖过程中产生的一种胞内酶,可以调节宿主的胆汁酸平衡,影响脂质代谢,有控制胆固醇、调节肠道疾病的作用,并且BSH这种调控作用可以实现益生菌部分益生功能,因此BSH一直是研究热点。BSH结构和底物特异性的详细知识是开发BSH相关产品的坚实基础。本文介绍了BSH的来源及活性检测方法,BSH基因结构、酶学性质及底物识别机制,最后讨论了BSH在畜禽业食品工业及医药等方面的应用,期望为胆盐水解酶的深入研究及其在食品、保健品及医药方面的开发利用提供参考。Bile salt hydrolase(BSH)is an intracellular enzyme which is produced by intestinal flora during the period of growth and reproduction.This enzyme has been suggested to be involved in the host's bile acid balance,lipid metabolism and metabolic responses.Therefore,BSH has always been a research hotspot.Detailed knowledge of BSH structure and substrate preferences is a solid foundation for the development of BSH related products.This review explains the source and distribution of BSH,test method for BSH activity.It also introduces enzymatic properties and genetic organization.Finally,the potential applications of BSH research are briefly discussed.This review would provide theoretical basis for the in-depth research of BSH,developments of related functional foods,and other industry applications.

关 键 词：胆盐水解酶 肠道微生物 酶学性质 结构基础 应用 

分 类 号：Q556[生物学—生物化学]