Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice  

作　　者：Chen Wang Junying Bai Botao Wang Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Huayi Suo Wei Chen Qixiao Zhai 

机构地区：[1]College of Food Science,Southwest University,Chongqing 400715,China [2]State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China [3]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [4]Bloomage Biotechnology Co.,Ltd.,Jinan 250000,China [5]National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China [6]Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch,Wuxi 214122,China

出　　处：《Food Science and Human Wellness》2023年第6期2211-2220,共10页食品科学与人类健康（英文）

摘　　要：Stachyose is a prebiotic that traditionally extracted from plants,such as vegetable.It has been demonstrated to alleviate intestinal inflammation by regulating gut microbiota,but the mechanism has been unclear.This research aims to detect the potential mechanism of stachyose in alleviating the severity of ulcerative colitis(UC).The results indicated that the administration of stachyose could recover the body weight,protect against the colonic tissue damage,reduce the pro-inflammatory cytokines levels,and reverse the histological abnormalities in UC mice.Oral stachyose could restore dextran sulfate sodium(DSS)-induced disturbance in intestinal bacteria.Besides,the metabolome result of serum samples showed that stachyose treatment significantly altered serum metabolites against inflammatory responses in colitis mice.Also,a significant correlation can be found between 23 metabolite biomarkers and 18 differential genera.Our results provided a strong foundation for the future study of the protective role of stachyose in maintaining intestinal homeostasis.

关 键 词：STACHYOSE Prebiotic COLITIS METABONOMICS Gut microbiota 

分 类 号：TS201.4[轻工技术与工程—食品科学]