Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism  

作　　者：Peng Lei Jialin Lü Tie Yao Peng Zhang Xin Chai Yuefei Wang Miaomiao Jiang 

机构地区：[1]State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [2]Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae,Ministry of Education,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

出　　处：《Food Science and Human Wellness》2023年第6期2314-2323,共10页食品科学与人类健康（英文）

基　　金：supported by the Tianjin Science and Technology Project(21ZYJDJC00080)and(20ZYJDJC00120);the Natural Science Foundation of Tianjin(18JCZDJC97700);the Natural Science Foundation of China(81573547).

摘　　要：Verbascoside,abundant in olive mill wastewater,is a phenylethanolic glycoside with a wide range of pharmacological activities.Atherosclerosis(AS)is a common metabolic disease and abnormal lipid metabolism in liver is inseparable from its formation and development.In this study,the anti-atherosclerotic effect of verbascoside was evaluated by establishing an atherosclerosis model based on western diet feeding of apolipoprotein E-defi cient mice for 16 weeks.After 12 weeks of administration during the feeding period,the levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)in the plasma of mice were signifi cantly decreased,the formation of arterial plaques was delayed,and the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and lactate dehydrogenase(LDH)in plasma were alleviated,showing the hepatoprotective effect.In addition,based on untargeted lipidomic analysis,verbascoside stabilized glycerophospholipid metabolism,modulated lipid metabolism disorders and reduced lipid deposition in the liver to achieve the therapeutic effi cacy against atherosclerosis by regulating cardiolipin(CL),ether-linked phosphatidylcholine(ether-PC),lysophophatidylcholine(LPC),phosphatidylcholine(PC),oxidized phosphatidylcholine(OxPC),oxidized phosphatidylethanolamine(OxPE),triacylglycerol(TG),sphingomyelin(SM)back to normal levels.

关 键 词：ATHEROSCLEROSIS VERBASCOSIDE Lipid deposition LIPIDOMICS Glycerophospholipid metabolism 

分 类 号：R285.5[医药卫生—中药学]