Cytokines,synaptic plasticity and network dynamics:a matter of balance  

作　　者：Laura Bellingacci Jacopo Canonichesi Andrea Mancini Lucilla Parnetti Massimiliano Di Filippo 

机构地区：[1]Section of Neurology,Department of Medicine and Surgery,University of Perugia,Perugia,Italy

出　　处：《Neural Regeneration Research》2023年第12期2569-2572,共4页中国神经再生研究（英文版）

摘　　要：The modern view of the immune system as a sensitizing and modulating machinery of the central nervous system is now well recognized.However,the specific mechanisms underlying this fine crosstalk have yet to be fully disentangled.To control cognitive function and behavior,the two systems are engaged in a subtle interacting act.In this scenario,a dual action of pro-inflammatory cytokines in the modulation of brain network connections is emerging.Pro-inflammatory cytokines are indeed required to express physiological plasticity in the hippocampal network while being detrimental when over-expressed during uncontrolled inflammatory processes.In this dynamic equilibrium,synaptic functioning and the performance of neural networks are ensured by maintaining an appropriate balance between pro-and anti-inflammatory molecules in the central nervous system microenvironment.

关 键 词：brain networks COGNITION CYTOKINES HIPPOCAMPUS memory NEUROIMMUNOLOGY NEUROINFLAMMATION synaptic plasticity 

分 类 号：R338.1[医药卫生—人体生理学]