β-丙氨酸的生物代谢过程及生物法制备研究进展  

Research progress on bio-metabolic pathways and biopreparation ofβ-alanine

作　　者：丁乾 段绪果 DING Qian;DUAN Xuguo(College of Light Industry and Food Engineering,Nanjing Forestry University,Nanjing 210037,Jiangsu,China)

机构地区：[1]南京林业大学轻工与食品学院,江苏南京210037

出　　处：《精细化工》2023年第4期741-753,共13页Fine Chemicals

基　　金：江苏省高校优秀中青年教师和校长境外研修计划项目;南京林业大学青年拔尖人才项目(GXL2018010)。

摘　　要：β-丙氨酸是自然界中唯一一种天然存在的β型氨基酸,也是一种非蛋白氨基酸。β-丙氨酸在食品、医药、化工和饲料等领域具有重要用途,市场前景非常广阔。目前,β-丙氨酸的合成方法有化学法和生物法。相较于化学法复杂的生产流程,生物法具有产物专一、条件温和及工艺简单等优点,是公认的更环保、更有前景的β-丙氨酸生产方法。该文综述了β-丙氨酸的性质、应用、生物代谢路径及主要的生物合成法,重点讨论了生物法生产β-丙氨酸的现状及存在的问题。以期为β-丙氨酸的高效、绿色生产工艺开发及工业化应用提供参考。β-Alanine,a non-protein amino acid,is the only naturally existingβ-type amino acid in nature,which has important applications in the food industry,pharmaceutical industry,chemical industry,feed industry,and other fields,and broad market potential.At present,chemical synthesis and biosynthesis are the two methods forβ-alanine synthesis.In comparison to the chemical method with complex production process,the biological method,showing the advantages of product specificity,mild conditions,and simple process,is recognized as a more environmental-friendly and promisingβ-alanine production method.Herein,the properties,applications,biological metabolic processes and main biological preparation methods ofβ-alanine were reviewed,with emphasis on the current situation and existing problems of biological production method.This review is expected to provide reference for the development of efficient and green production process and industrial application ofβ-alanine in the future.

关 键 词：Β-丙氨酸 生物法 发酵法 酶转化 L-天冬氨酸-α-脱羧酶 

分 类 号：TQ922.2[轻工技术与工程—发酵工程]