Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth  

作　　者：Juan Jin Li Li Caiyun Fu 

机构地区：[1]Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine,College of Life Sciences and Medicine,Zhejiang Sci-Tech University,310018,Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第2期333-334,共2页信号转导与靶向治疗（英文）

基　　金：This work was supported by the Zhejiang Provincial Natural and Science Foundation of China under Grant No.LD22H310004.

摘　　要：In a recent study published in Nature,Mitchell E.Fane et al.revealed the critical role of the aged microenvironment in the reactivation of melanoma cells from dormancy.1 The authors found that age-induced lung fibroblast secretory changes promoted growth activation of dormant melanoma cells in the lung,and age-induced skin microenvironment changes suppressed melanoma growth but promoted melanoma cell dissemination(Fig.1).

关 键 词：MELANOMA LUNG MICROENVIRONMENT 

分 类 号：R739.5[医药卫生—肿瘤]