The cGAS-STING pathway:a therapeutic target in chromosomally unstable cancers  

作　　者：Haiyan Yan Weiguo Lu Fangwei Wang 

机构地区：[1]Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province,School of Medicine,Hangzhou City University,310015,Hangzhou,China [2]Women’s Hospital,Zhejiang University School of Medicine,310006,Hangzhou,China [3]Cancer Center,Zhejiang University,310058,Hangzhou,China [4]The MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology,Life Sciences Institute,Zhejiang University,310058,Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第2期338-340,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the National Key Research and Development Program of China(2022YFA1105200,2022YFA1303100);the National Natural Science Foundation of China(32025011,32270772,31771499,and 32061160470);Natural Science Foundation of Zhejiang Province(LZ19C070001,LY17C070003).We also thank Dr.Qinfu Chen for the help to draft the artwork.

摘　　要：In a recent study published in Nature,Hong et al.revealed that the cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)innate immune pathway is critically required for the IL-6-dependent survival of chromosomally unstable cancer cells,1 implying that chronic inflammation can be therapeutically targeted to kill cancers displaying chromosomal instability(CIN).

关 键 词：UNSTABLE CHROMOSOMAL THERAPEUTIC 

分 类 号：R730.5[医药卫生—肿瘤]