CTRP family in diseases associated with inflammation and metabolism:molecular mechanisms and clinical implication  

作　　者：Huan Zhang Zi-yin Zhang-Sun Cheng-xu Xue Xi-yang Li Jun Ren Yu-ting Jiang Tong Liu Hai-rong Yao Juan Zhang Tian-tian Gou Ye Tian Wang-rui Lei Yang Yang 

机构地区：[1]Department of Cardiology,Xi’an No.3 Hospital/The Affiliated Hospital of Northwest University,Faculty of Life Sciences and Medicine,Northwest University,Xi’an 710021,China [2]Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,Faculty of Life Sciences and Medicine,Northwest University,Xi’an 710069,China [3]Department of Cardiology,Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital Fudan University,Shanghai 200032,China

出　　处：《Acta Pharmacologica Sinica》2023年第4期710-725,共16页中国药理学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(81871607 and 82070422);Youth Science and Technology Rising Star Project of Shaanxi Province(2020KJXX-036);High-end Foreign Expert Introduction Program of National Science and Technology(G2022040014L);Innovation Capability Strong Foundation Plan of Xi'an City(Medical Research Project,21YXYJ0037);Major Research Projects of Xian Science and Technology Plan[201805104YX12SF38(2)].

摘　　要：C1q/tumor necrosis factor(TNF)related proteins(CTRPs)is a newly discovered adipokine family with conservative structure and ubiquitous distribution and is secreted by adipose tissues.Recently,CTRPs have attracted increasing attention due to the its wide-ranging effects upon inflammation and metabolism.To-date,15 members of CTRPs(CTRP1-15)with the characteristic C1q domain have been characterized.Earlier in-depth phenotypic analyses of mouse models of CTRPs deficiency have also unveiled ample function of CTRPs in inflammation and metabolism.This review focuses on the rise of CTRPs,with a special emphasis on the latest discoveries with regards to the effects of the CTRP family on inflammation and metabolism as well as related diseases.We first introduced the structure of characteristic domain and polymerization of CTRPs to reveal its pleiotropic biological functions.Next,intimate association of CTRP family with inflammation and metabolism,as well as the involvement of CTRPs as nodes in complex molecular networks,were elaborated.With expanding membership of CTRP family,the information presented here provides new perspectives for therapeutic strategies to improve inflammatory and metabolic abnormalities.

关 键 词：CTRPs ADIPOKINE INFLAMMATION METABOLISM ATHEROSCLEROSIS heart diseases 

分 类 号：R96[医药卫生—药理学]