Metabolic strategy of macrophages under homeostasis or immune stress in Drosophila  

作　　者：Wang Luo Sumin Liu Fang Zhang Long Zhao Ying Su 

机构地区：[1]Institute of Evolution and Marine Biodiversity,Ocean University of China,Qingdao 266003,China [2]College of Marine Life Sciences,Ocean University of China,Qingdao 266003,China [3]Fisheries College,Ocean University of China,Qingdao 266003,China [4]Key Laboratory of Mariculture(OUC),Ministry of Education,Qingdao 266003,China

出　　处：《Marine Life Science & Technology》2022年第3期291-302,共12页海洋生命科学与技术（英文）

基　　金：supported by the grants of the National Natural Science Foundation of China(31970475 and 32170832 to YS,31970506 and 32170541 to LZ);the Fundamen-tal Research Funds for Central Universities,China(202012004 to LZ).

摘　　要：Macrophages are well known for their phagocytic functions in innate immunity across species.In mammals,they rapidly consume a large amount of energy by shifting their metabolism from mitochondrial oxidative phosphorylation toward aerobic glycolysis,to perform the effective bactericidal function upon infection.Meanwhile,they strive for sufficient energy resources by restricting systemic metabolism.In contrast,under nutrient deprivation,the macrophage population is down-regulated to save energy for survival.Drosophila melanogaster possesses a highly conserved and comparatively simple innate immune system.Intriguingly,recent studies have shown that Drosophila plasmatocytes,the macrophage-like blood cells,adopt comparable metabolic remodeling and signaling pathways to achieve energy reassignment when challenged by pathogens,indicating the conservation of such metabolic strategies between insects and mammals.Here,focusing on Drosophila macrophages(plasmatocytes),we review recent advances regarding their comprehensive roles in local or systemic metabolism under homeostasis or stress,emphasizing macrophages as critical players in the crosstalk between the immune system and organic metabolism from a Drosophila perspective.

关 键 词：MACROPHAGE DROSOPHILA Immune system Metabolism PLASMATOCYTE 

分 类 号：Q96[生物学—昆虫学]