Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production  

作　　者：Shu-min KONG Xiao-yan SUN Wen-ya CUI Yu-chun CAO 

机构地区：[1]Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China

出　　处：《Current Medical Science》2023年第2期399-408,共10页当代医学科学（英文）

基　　金：supported by a grant from the National Natural Science Foundation of China(No.81974308).

摘　　要：Objective Psoriasis is often combined with metabolic abnormalities,such as obesity and diabetes.The upregulation of chemerin,which is an essential protein produced primarily from white fat,is strongly correlated to the development of psoriasis.However,there is no clarification on its exact function and mechanism in disease pathogenesis.The present study aims to determine its function and mechanism in disease pathogenesis.Methods The present study used a psoriasislike inflammatory cell model and imiquimod(IMQ)-induced mouse model to confirm whether chemerin is upregulated in psoriasis patients.Results Chemerin enhanced the keratinocyte proliferation,inflammatory cytokine secretion,and activation of the MAPK signaling pathway.Crucially,the intraperitoneal injection of neutralizing anti-chemerin antibody(ChAb)diminished the epidermal proliferation and inflammation in the IMQ-induced mouse model.Conclusion The present results indicate that chemerin promotes keratinocyte proliferation,and enhances the production of inflammatory cytokines,thereby aggravating the psoriasis.Thus,chemerin can be a prospective target for the treatment of psoriasis.

关 键 词：PSORIASIS KERATINOCYTE CHEMERIN PROLIFERATION INFLAMMATION 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]