MV-mediated biomineralization mechanisms and treatments of biomineralized diseases  

作　　者：Xuan Li Wei Zhang Yubo Fan Xufeng Niu 

机构地区：[1]Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,China [2]TIANXINFU(Beijing)Medical Appliance Co.,Ltd.,Beijing,102200,China [3]School of Engineering Medicine,Beihang University,Beijing,100083,China

出　　处：《Medicine in Novel Technology and Devices》2023年第1期1-14,共14页医学中新技术与新装备（英文）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.12272032,11872097,11827803 and U20A20390);the National Key R&D Program of China(No.2020YFC0122204);the 111 Project(No.B13003).

摘　　要：As the quality of life improves,people pay more and more attention to health.They are concerned about the causes of diseases,and seek better treatments.The most common diseases are biomineralized diseases,four different kinds of typical examples among which are selected to elaborate their mechanisms and existing treatments.Whether it is tooth and bone in physiological mineralization or cartilage and blood vessel in pathological mineralization,they are all related to matrix vesicle(MV)-mediated biomineralization.MV-mediated biomineralization is the initial stage of biomineralization and the nucleation site mediating collagen mineralization.Definition,composition,biogenesis,and action mechanism of MVs are refined and expounded,especially a novel biomineralization pathway similar to exosome(EX)origin.Four differences are summarized to distinguish MVs and EXs.A series of treatments using MVs to solve biomineralized diseases such as tooth and bone defects,osteoarthritis and atherosclerosis are proposed,and the experimental extraction steps of MVs are summarized.

关 键 词：Matrix vesicle BIOMINERALIZATION BIOGENESIS OSTEOARTHRITIS ATHEROSCLEROSIS 

分 类 号：R318[医药卫生—生物医学工程]