基于天然大分子的黄酮类化合物纳米颗粒的研究进展  

Research Progress on Nanoparticles of Flavonoids Based on Natural Macromolecules

作　　者：高琦[1,2] 陈文钊 唐子程 彭雪 王宁[1] 薛友林 GAO Qi;CHEN Wenzhao;TANG Zicheng;PENG Xue;WANG Ning;XUE Youlin(Collage of Light Industry,Liaoning University,Shenyang 110036,China;Party School of Liaoning Provincial Party Committee,Shenyang 110161,China)

机构地区：[1]辽宁大学轻型产业学院,辽宁沈阳110036 [2]中共辽宁省委党校,辽宁沈阳110161

出　　处：《食品工业科技》2023年第11期20-29,共10页Science and Technology of Food Industry

基　　金：教育部新农科研究与改革实践项目(2020128);教育部产学合作协同育人项目(202002115014,202102654021);辽宁省“兴辽英才计划”项目(XLYC1807270);辽宁省教育厅基本科研服务地方项目(LJKFZ20220183);泰州市高层次创新创业人才引进计划项目(202149);辽宁大学大学生创新创业训练计划项目(202210140009X,X202210140041,S202210140027)。

摘　　要：黄酮类化合物是存在于天然食品中一类重要的多酚类化合物,在食品、药品、保健品和化妆品等行业具有极大的应用潜力。然而黄酮类化合物却普遍因为自身的溶解度低、稳定性和渗透性差,导致其生物利用度差,因而限制了其在食品中的应用。利用纳米技术,以天然生物大分子为基质制备黄酮类化合物的纳米颗粒,进而改善黄酮类化合物的理化性质,是一种很有前途的策略。本文综合近年来国内外研究,简单介绍了黄酮类化合物的结构与性质,在此基础上,例举了多种蛋白质和多糖基质的纳米颗粒及相关的研究成果,讨论其结合机理和适用性,并展望黄酮类化合物纳米颗粒在食品行业中应用的发展前景。旨在为黄酮类化合物天然大分子纳米颗粒的开发利用提供理论基础和依据。Flavonoids are an important group of polyphenolic compounds found in natural foods,showing great potential for the usage in food,pharmaceutical,nutraceutical,and cosmetic industries.Nevertheless,flavonoids are generally limited in their potential application in food industry due to their low solubility,poor stability and permeability,resulting in poor bioavailability.It is a promising strategy to use nanotechnology to prepare nanoparticles of flavonoids based on natural biological macromolecules and thus improve the physicochemical properties of flavonoids.Recent researches at home and abroad are comprehensive analyzed in this paper,and the structure and properties of flavonoids are briefly described.On this basis,examples of nanoparticles of various protein and polysaccharide matrices and related research results are presented in this paper to discuss their binding mechanisms and applicability.The development of flavonoid nanoparticles for applications in the food industry is also envisaged.The objective of this study is to provide a theoretical basis and rationale for the development and utilization of natural macromolecular nanoparticles of flavonoids.

关 键 词：黄酮类化合物 天然大分子 纳米颗粒 稳定性 生物利用率 

分 类 号：TS201.2[轻工技术与工程—食品科学]