The role of latanoprost in an inflammatory bowel disease flare  

作　　者：Sonali Paul Martin Wand Geoffrey T.Emerick James M.Richter 

机构地区：[1]Department of Gastroenterology and Hepatology,Tufts Medical Center,Boston,MA,USA [2]Department of Ophthalmology,University of Connecticut School of Medicine and Consulting Ophthalmologists,Farmington,CT,USA [3]Department of Gastroenterology,Massachusetts General Hospital,Boston,MA,USA

出　　处：《Gastroenterology Report》2014年第3期232-234,共3页胃肠病学报道（英文）

基　　金：supported by the 2013–2014 Bristol-Myers Squibb Virology Fellows Research Training Program.The manuscript received no direct financial support.

摘　　要：Ulcerative colitis and Crohn’s disease(CD)are characterized by inflammation of the intestinal mucosa and symptoms of abdominal pain and diarrhea.Many studies have shown an association between elevated levels of prostaglandins and mucosal damage in inflammatory bowel disease.We report a 50-year-old woman with a history of CD and open-angle glaucoma.Her glaucoma was treated with latanoprost,a prostaglandin analog,which was associated with an exacerbation of her CD.On discontinuation of latanoprost,her CD symptoms disappeared completely.This case suggests that in a patient with CD,topical administration of latanoprost may result in sufficient systemic absorption and circulation to promote a relapse of CD.This finding has important implications,not only for patients with inflammatory bowel disease and glaucoma,but also for both ophthalmologists and gastroenterologists.

关 键 词：lantanoprost Crohn’s disease PROSTAGLANDIN GLAUCOMA 

分 类 号：R57[医药卫生—消化系统]