A case of cerebral venous sinus thrombosis associated with Crohn’s disease:dilemma in management  

克罗恩病合并脑静脉窦血栓形成一例:治疗困境

作　　者：Younghoon Kwon Ryan J Koene Yeilim Cho 

机构地区：[1]St.Joseph’s Hospital,HealthEast Care System,Saint Paul,Minnesota,USA [2]Department of Medicine,University of Minnesota,Minneapolis,Minnesota,USA

出　　处：《Gastroenterology Report》2016年第2期154-157,I0003,共5页胃肠病学报道（英文）

基　　金：The authors would like to thank Thinesh Sivapatham,MD and Michael T.Madison,MD of Saint Paul Radiology for reviewing the images enclosed in this manuscript.

摘　　要：Inflammatory bowel disease(IBD)is known to increase the risk of venous thromboembolism.Cerebral venous sinus thrombosis(CVST)is a rare but important complication of IBD.Timely diagnosis,particularly in younger patients,requires a high level of suspicion in order to prevent potentially devastating complications such as hemorrhage or venous infarction.The paper presents a 44-year-old Caucasian woman with a previous history of Crohn’s disease and deep venous thrombosis.Magnetic resonance imaging confirmed the diagnosis of CVST.Achieving therapeutic anticoagulation with warfarin was difficult,due to presumed pharmacological interaction between warfarin and 6-mercaptopurine.Clinicians should have a high index of suspicion for CVST when a patient with Crohn’s disease presents with acute headache,and be aware of challenges related to medical management.

关 键 词：cerebral venous sinus thrombosis Crohn’s disease ANTICOAGULATION MERCAPTOPURINE WARFARIN 

分 类 号：R57[医药卫生—消化系统]