Intestinal cellular heterogeneity and disease development revealed by single-cell technology  

作　　者：Yalong Wang Wanlu Song Shicheng Yu Yuan Liu Ye-Guang Chen 

机构地区：[1]Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sci-ences,Guangzhou Science Park,Luogang District,Guangzhou,China [2]Guang-zhou Laboratory,Guangzhou,China [3]The State Key Laboratory of Membrane Biology,Tsinghua-Peking Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing,China

出　　处：《Cell Regeneration》2022年第1期267-289,共23页细胞再生（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(31988101 and 31900550);the Guangdong Postdoctoral Research Foundation(O0390302);Guangdong Basic and Applied Basic Research Foundation(2021A1515111215);China Postdoctoral Science Foundation(2021M703230 and 2022T150653).

摘　　要：The intestinal epithelium is responsible for food digestion and nutrient absorption and plays a critical role in hormone secretion,microorganism defense,and immune response.These functions depend on the integral single-layered intestinal epithelium,which shows diversified cell constitution and rapid self-renewal and presents powerful regen-eration plasticity after injury.Derailment of homeostasis of the intestine epithelium leads to the development of dis-eases,most commonly including enteritis and colorectal cancer.Therefore,it is important to understand the cellular characterization of the intestinal epithelium at the molecular level and the mechanisms underlying its homeostatic maintenance.Single-cell technologies allow us to gain molecular insights at the single-cell level.In this review,we summarize the single-cell RNA sequencing applications to understand intestinal cell characteristics,spatiotemporal evolution,and intestinal disease development.

关 键 词：scRNA-seq GUT HETEROGENEITY ENTERITIS Colorectal cancer 

分 类 号：R574[医药卫生—消化系统] R329.2[医药卫生—内科学]