Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases  

作　　者：Kareem Khalaf Paolo Tornese Antoniangela Cocco Alberto Albanese 

机构地区：[1]Department of Neurology,IRCCS Humanitas Research Hospital,Rozzano,MI,Italy

出　　处：《Translational Neurodegeneration》2022年第1期444-460,共17页转化神经变性病（英文）

基　　金：Funded by the European Union’s Horizon 2020 research and innovation program under grant agreement No 755094 to AA.

摘　　要：Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded aggregates accumulating. The neurodegenerative process is mediated by numerous metabolic pathways, most of which lead to apoptosis. In recent years, hydrophilic bile acids, particularly tauroursodeoxycholic acid (TUDCA), have shown important anti-apoptotic and neuroprotective activities, with numerous experimental and clinical evidence suggesting their possible therapeutic use as disease-modifiers in neurodegenerative diseases. Experimental evidence on the mechanisms underlying TUDCA’s neuroprotective action derives from animal models of Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases, amyotrophic lateral sclerosis (ALS) and cerebral ischemia. Preclinical studies indicate that TUDCA exerts its effects not only by regulating and inhibiting the apoptotic cascade, but also by reducing oxidative stress, protecting the mitochondria, producing an anti-neuroinflammatory action, and acting as a chemical chaperone to maintain the stability and correct folding of proteins. Furthermore, data from phase II clinical trials have shown TUDCA to be safe and a potential disease-modifier in ALS. ALS is the first neurodegenerative disease being treated with hydrophilic bile acids. While further clinical evidence is being accumulated for the other diseases, TUDCA stands as a promising treatment for neurodegenerative diseases.

关 键 词：Amyotrophic lateral sclerosis Alzheimer’s disease Bile acids Disease-modifying Huntington’s disease NEURODEGENERATION NEUROPROTECTION Parkinson’s disease Ursodeoxycholic acid Tauroursodeoxycholic acid 

分 类 号：R741[医药卫生—神经病学与精神病学]