Defective mitophagy and the etiopathogenesis of Alzheimer’s disease  

作　　者：Kuan Zeng Xuan Yu Yacoubou Abdoul Razak Mahaman Jian-Zhi Wang Rong Liu Yi Li Xiaochuan Wang 

机构地区：[1]Department of Psychiatry,Wuhan Mental Health Center,Wuhan 430012,China [2]Co-Innovation Center of Neurodegeneration,Nantong University,Nantong 226001,China [3]Department of Pathophysiology,School of Basic Medicine,Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [4]Wuhan Hospital for Psychotherapy,Wuhan 430012,China [5]Shenzhen Huazhong University of Science and Technology Research Institute,Shenzhen 518000,China.

出　　处：《Translational Neurodegeneration》2022年第1期461-473,共13页转化神经变性病（英文）

基　　金：grants from National Natural Science Foundation of China(31929002,92049107 and 81801077);Innovative Research Groups of the National Natural Science Foundation of China(81721005);Youth Program of Wuhan Municipal Health Commission Foundation(WX18Q41);Technology and Innovation Commission of Shenzhen Municipality(JCYJ20210324141405014);Guangdong Basic and Applied Basic Research Foundation(2020B1515120017)and the Academic Frontier Youth Team Project to Xiaochuan Wang from Huazhong University of Science and Technology.

摘　　要：Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration,including Alzheimer’s disease(AD).A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development.The interaction between mitophagy deficits and Aβor Tau pathology may form a vicious cycle and cause neuronal damage and death.Elucidating the molecular mechanism of mitophagy and its role in AD may provide insights into the etiology and mechanisms of AD.Defective mitophagy is a potential target for AD prevention and treatment.

关 键 词：MITOPHAGY Alzheimer’s disease PINK1 TAU Aβ 

分 类 号：R749.16[医药卫生—神经病学与精神病学]