The role of VISTA in the tumor microenvironment  

作　　者：Dina Rabadi Alia A.Sajani Randolph J.Noelle J.Louise Lines 

机构地区：[1]Department of Biological Sciences,Dartmouth College,Hanover,NH 03755,USA [2]Department of Microbiology and Immunology,Norris Cotton Cancer Center,Geisel School of Medicine at Dartmouth,Lebanon,NH 03756,USA

出　　处：《Journal of Cancer Metastasis and Treatment》2022年第1期365-378,共14页癌症转移与治疗（英文版）

基　　金：Research was supported by NIH grants R01AR070760 and R01CA214062(Randolph J.Noelle).

摘　　要：V-domain Ig Suppressor of T cell Activation(VISTA)is a negative immune checkpoint that is expressed on multiple immune cell subsets and has been characterized in T cells,macrophages,and myeloid-derived suppressor cells.As the only immune checkpoint expressed on naïve T cells,VISTA contributes to the maintenance of T cell quiescence and tolerance.VISTA also regulates multiple myeloid cell activities such as chemotaxis,differentiation,and migration.In the context of cancer,antagonistic monoclonal antibody targeting of VISTA has been shown to aid anti-tumor immunity.Furthermore,combination therapies that include other immune checkpoints such as PD-1 or CTLA-4 with VISTA blockade may enhance therapeutic efficacy in a variety of cancers.Combination therapy may help overcome adaptive resistance to individual checkpoint therapies,thereby improving patient outcomes and survival.Here,we summarize the role of VISTA in myeloid cells and T cells within the tumor microenvironment.We discuss the proposed counter-receptors for VISTA,VISTA antibodies currently in development,and the potential for combination therapies with checkpoint inhibitors such as PD-1 and CTLA-4.

关 键 词：VISTA CANCER MDSC immune checkpoint 

分 类 号：R730.2[医药卫生—肿瘤]