Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course:a report of two cases  

作　　者：Toni Valković Marija StanićDamić Frane Valković Nives Jonjić 

机构地区：[1]Department of Hematology,University Hospital Rijeka,Rijeka 51000,Croatia [2]Faculty of Medicine Rijeka,University of Rijeka,Rijeka 51000,Croatia [3]Faculty of Health Studies,University of Rijeka,Rijeka 51000,Croatia [4]Department of Pathology and Cytology,University Hospital Rijeka,Rijeka 51000,Croatia

出　　处：《Journal of Cancer Metastasis and Treatment》2022年第1期624-630,共7页癌症转移与治疗（英文版）

基　　金：This work was supported by the Research Support of the University of Rijeka:grant No.918.10.0104。

摘　　要：Extramedullary disease(EMD)of multiple myeloma(MM)can present as paraskeletal(paraosseous)plasmocytoma(PP)that arise from skeletal focal lesions or extramedullary plasmacytomas(EMP)that derive from hematogenous spread.The pathogenetic mechanisms that distinguish classical MM,PP,and EMP are still insufficiently known,as are the therapies that would be effective in EMD.The aim of this study was to evaluate immunohistochemically the angiogenesis,determined as microvessel density(MVD)and osteopontin expression in PP,of two patients with MM of plasmablastic morphology and an aggressive course of disease.We found high levels of MVD and osteopontin expression in both cases of PP.The role of angiogenesis and osteopontin in EMD should be clarified in future investigations,especially since there are no satisfactory therapeutic protocols for this form of multiple myeloma,and both of these biological factors can be the potential targets of new therapies.

关 键 词：Extramedullary myeloma paraskeletal plasmacytoma OSTEOPONTIN ANGIOGENESIS plasmablastic morphology 

分 类 号：R733.3[医药卫生—肿瘤]