Triggering of Major Brain Disorders by Protons and ATP:The Role of ASICs and P2X Receptors  

作　　者：Andri Cherninskyi Maksim Storozhuk Oleksandr Maximyuk Vyacheslav Kulyk Oleg Krishtal 

机构地区：[1]Bogomoletz Institute of Physiology of National Academy of Sciences of Ukraine,Kyiv 01024,Ukraine

出　　处：《Neuroscience Bulletin》2023年第5期845-862,共18页神经科学通报（英文版）

基　　金：supported by the National Research Foundation of Ukraine(https:/nrfu.org.ua/en/,2020.02/0263);Die Deutsche Forschungsgemeinschaft(https://www.dfg.del,441694049).

摘　　要：Adenosine triphosphate(ATP)is well-known as a universal source of energy in living cells.Less known is that this molecule has a variety of important signaling func-tions:it activates a variety of specific metabotropic(P2Y)and ionotropic(P2X)receptors in neuronal and non-neu-ronal cell membranes.So,a wide variety of signaling func-tions well fits the ubiquitous presence of ATP in the tissues.Even more ubiquitous are protons.Apart from the unspe-cific interaction of protons with any protein,many physi-ological processes are affected by protons acting on specific ionotropic receptors--acid-sensing ion channels(ASICs).Both protons(acidification)and ATP are locally elevated in various pathological states.Using these fundamentally important molecules as agonists,ASICs and P2X receptors signal a variety of major brain pathologies.Here we briefly outline the physiological roles of ASICs and P2X receptors,focusing on the brain pathologies involving these receptors.

关 键 词：ASICS P2X receptors STROKE Chronic pain EPILEPSY NEURODEGENERATIVE Psychiatric diseases 

分 类 号：R749.4[医药卫生—神经病学与精神病学]